AJP - Regu Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 275: R180-R185, 1998;
0363-6119/98 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kahler, A.
Right arrow Articles by Langhans, W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kahler, A.
Right arrow Articles by Langhans, W.
Vol. 275, Issue 1, R180-R185, July 1998

Chronic administration of OB protein decreases food intake by selectively reducing meal size in male rats

Andrea Kahler1, Nori Geary2, Lisa A. Eckel2, L. Arthur Campfield3, Françoise J. Smith3, and Wolfgang Langhans1

1 Institute for Animal Sciences, Swiss Federal Institute of Technology, 8092 Zurich, Switzerland; 2 E. W. Bourne Laboratory, New York Hospital-Cornell Medical Center, White Plains, New York 10605; and 3 Department of Metabolic Diseases, Hoffmann-La Roche, Nutley, New Jersey 07110

The potent hypophagic effect of OB protein (OB) is well established, but the mechanism of this effect is largely unknown. We investigated the effects of chronic administration of a novel modified recombinant human OB (Mod-OB) with a prolonged half-life (>48 h) on ad libitum food intake, spontaneous meal patterns, and body weight in 24 adult, male Sprague-Dawley rats (body weight at study onset: 292 g). Single daily subcutaneous injections of Mod-OB (4 mg/kg daily) for 8 consecutive days significantly reduced ad libitum food intake compared with vehicle injections from injection day 3 through postinjection day 3. Mod-OB-injected rats ate between 4.5 and 7.1 g (or 13-20%) per day less than controls, with the reduction primarily occurring during the dark period. Body weight gain was significantly decreased in response to Mod-OB from injection day 8 until postinjection day 4, with a maximum difference of 24 g on postinjection day 3. The reduction of food intake by Mod-OB was mainly due to a 21-34% decrease in nocturnal spontaneous meal size. There was no significant effect of Mod-OB on nocturnal meal frequency or duration. Mod-OB also did not reliably affect the size, duration, or frequency of diurnal meals. Mod-OB-injected rats displayed no compensatory hyperphagia after the injection period. These results indicate that chronically administered OB selectively affects the mechanisms controlling meal size in male rats.

leptin; adiposity; obesity; satiety; spontaneous feeding


This article has been cited by other articles:


Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
B. Ferrari, M. Arnold, R. D. Carr, W. Langhans, G. Pacini, T. B. Bodvarsdottir, and D. X. Gram
Subdiaphragmatic vagal deafferentation affects body weight gain and glucose metabolism in obese male Zucker (fa/fa) rats
Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2005; 289(4): R1027 - R1034.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
K. A. Singh, C. N. Boozer, and J. R. Vasselli
Acute insulin-induced elevations of circulating leptin and feeding inhibition in lean but not obese rats
Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2005; 289(2): R373 - R379.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
E. E. Ladenheim, M. Emond, and T. H. Moran
Leptin enhances feeding suppression and neural activation produced by systemically administered bombesin
Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2005; 289(2): R473 - R477.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
J. E. Blevins, M. W. Schwartz, and D. G. Baskin
Evidence that paraventricular nucleus oxytocin neurons link hypothalamic leptin action to caudal brain stem nuclei controlling meal size
Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2004; 287(1): R87 - R96.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
C. J Hukshorn, M. S Westerterp-Plantenga, and W. H. Saris
Pegylated human recombinant leptin (PEG-OB) causes additional weight loss in severely energy-restricted, overweight men
Am. J. Clinical Nutrition, April 1, 2003; 77(4): 771 - 776.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
I. Swart, J. W. Jahng, J. M. Overton, and T. A. Houpt
Hypothalamic NPY, AGRP, and POMC mRNA responses to leptin and refeeding in mice
Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2002; 283(5): R1020 - R1026.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
C. A. Matson, D. F. Reid, and R. C. Ritter
Daily CCK injection enhances reduction of body weight by chronic intracerebroventricular leptin infusion
Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2002; 282(5): R1368 - R1373.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
M. S Westerterp-Plantenga, W. H. Saris, C. J Hukshorn, and L A. Campfield
Effects of weekly administration of pegylated recombinant human OB protein on appetite profile and energy metabolism in obese men
Am. J. Clinical Nutrition, October 1, 2001; 74(4): 426 - 434.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
L. A. Eckel and N. Geary
Estradiol treatment increases feeding-induced c-Fos expression in the brains of ovariectomized rats
Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2001; 281(3): R738 - R746.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
T. Doi, M. Liu, R. J. Seeley, S. C. Woods, and P. Tso
Effect of leptin on intestinal apolipoprotein AIV in response to lipid feeding
Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2001; 281(3): R753 - R759.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
D. Chapelot, R. Aubert, C. Marmonier, M. Chabert, and J. Louis-Sylvestre
An endocrine and metabolic definition of the intermeal interval in humans: evidence for a role of leptin on the prandial pattern through fatty acid disposal
Am. J. Clinical Nutrition, August 1, 2000; 72(2): 421 - 431.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
H. F. Wildman, S. Chua Jr., R. L. Leibel, and G. P. Smith
Effects of leptin and cholecystokinin in rats with a null mutation of the leptin receptor Leprfak
Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2000; 278(6): R1518 - R1523.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
C. A. Matson, D. F. Reid, T. A. Cannon, and R. C. Ritter
Cholecystokinin and leptin act synergistically to reduce body weight
Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2000; 278(4): R882 - R890.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
F. Du, D. A. Higginbotham, and B. D. White
Food Intake, Energy Balance and Serum Leptin Concentrations in Rats Fed Low-Protein Diets
J. Nutr., March 1, 2000; 130(3): 514 - 521.
[Abstract] [Full Text]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
M. Emond, G. J. Schwartz, E. E. Ladenheim, and T. H. Moran
Central leptin modulates behavioral and neural responsivity to CCK
Am J Physiol Regulatory Integrative Comp Physiol, May 1, 1999; 276(5): R1545 - R1549.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
L. A. Eckel, W. Langhans, A. Kahler, L. A. Campfield, F. J. Smith, and N. Geary
Chronic administration of OB protein decreases food intake by selectively reducing meal size in female rats
Am J Physiol Regulatory Integrative Comp Physiol, July 1, 1998; 275(1): R186 - R193.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online