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Am J Physiol Regul Integr Comp Physiol 275: R29-R32, 1998;
0363-6119/98 $5.00
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Vol. 275, Issue 1, R29-R32, July 1998

Misty (m) affects growth traits

Gary E. Truett1, Robert J. Tempelman2, Jerilyn A. Walker1, and J. Krause Wilson1

1 Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808; and 2 Department of Animal Science, Michigan State University, East Lansing, Michigan 48824

The misty (m) coat color mutation is commonly maintained in linkage disequilibrium with the obesity mutation diabetes (Leprdb) to serve as a marker for Leprdb genotype. Comparisons among Leprdb genotypes are made under the untested assumption that m has no effects on traits under investigation. We tested this assumption in a population segregating m in the absence of db. Analysis of growth curves revealed that m/m mice are smaller than M/M mice by the 2nd wk of life and remain smaller through the 5th wk of life. Analysis of variance of three traits measured at 35 days of age revealed that m/m mice are 8% shorter than M/M mice, weigh 15% less, and have 21% less inguinal adipose mass. These results indicate that m affects growth traits. Therefore, when m and Leprdb segregate in the same cross, interpretation of their effects is confounded by linkage. More accurate estimates of Leprdb genotype effects can be made by removing m from populations segregating Leprdb and using a direct assay to measure Leprdb genotype.

leptin receptor; obese mice; db; obesity; diabetes


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