| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Thermoregulation Laboratory, Clinical Research and Technology, Legacy Holladay Park Medical Center, Portland, Oregon 97208
Recent evidence has suggested a role of abdominal vagal afferents in the pathogenesis of the febrile response. The abdominal vagus consists of five main branches (viz., the anterior and posterior celiac branches, anterior and posterior gastric branches, and hepatic branch). The branch responsible for transducing a pyrogenic signal from the periphery to the brain has not as yet been identified. In the present study, we address this issue by testing the febrile responsiveness of male Wistar rats subjected to one of four selective vagotomies: celiac (CBV), gastric (GBV), hepatic (HBV), or sham (SV). In the case of CBV, GBV, and HBV, only the particular vagal branch(es) was cut; for SV, all branches were left intact. After the postsurgical recovery (26-29 days), the rats had a catheter implanted into the jugular vein. On days 29-32, their colonic temperature (Tc) responses to a low dose (1 µg/kg) of Escherichia coli lipopolysaccharide (LPS) were studied. Three days later, the animals were subjected to a 24-h food and water deprivation, and the effectiveness of the four vagotomies to induce gastric food retention, pancreatic hypertrophy, and impairment of the portorenal osmotic reflex was assessed by weighing the stomach and pancreas and measuring the specific gravity of bladder urine, respectively. Stomach mass, pancreas mass, and urine density successfully separated the four experimental groups into four distinct clusters, thus confirming that each type of vagotomy had a different effect on the indexes measured. The Tc responses of SV, CBV, and GBV rats to LPS did not differ and were characterized by a latency of ~40 min and a maximal rise of 0.7 ± 0.1, 0.6 ± 0.1, and 0.9 ± 0.2°C, respectively. The fever response of the HBV rats was different; practically no Tc rise occurred (0.1 ± 0.2°C). The HBV appeared to be the only selective abdominal vagotomy affecting the febrile responsiveness. We conclude, therefore, that the hepatic vagus plays an important role in the transduction of a pyrogenic signal from the periphery to the brain.
temperature regulation; neuroimmunomodulation; febrile response; lipopolysaccharides; liver; selective vagotomy; rats
This article has been cited by other articles:
|
|
 |
|
  Y. Ootsuka, W. W. Blessing, A. A. Steiner, and A. A. Romanovsky Fever response to intravenous prostaglandin E2 is mediated by the brain but does not require afferent vagal signaling Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2008; 294(4): R1294 - R1303. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. P. Warne, M. T. Foster, H. F. Horneman, N. C. Pecoraro, H. K. de Jong, A. B. Ginsberg, S. F. Akana, and M. F. Dallman The gastroduodenal branch of the common hepatic vagus regulates voluntary lard intake, fat deposition, and plasma metabolites in streptozotocin-diabetic rats Am J Physiol Endocrinol Metab, January 1, 2008; 294(1): E190 - E200. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Feleder, V. Perlik, and C. M. Blatteis Preoptic nitric oxide attenuates endotoxic fever in guinea pigs by inhibiting the POA release of norepinephrine Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2007; 293(3): R1144 - R1151. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. J. Weiland, N. J. Voudouris, and S. Kent CCK2 receptor nullification attenuates lipopolysaccharide-induced sickness behavior Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2007; 292(1): R112 - R123. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Huston, M. Ochani, M. Rosas-Ballina, H. Liao, K. Ochani, V. A. Pavlov, M. Gallowitsch-Puerta, M. Ashok, C. J. Czura, B. Foxwell, et al. Splenectomy inactivates the cholinergic antiinflammatory pathway during lethal endotoxemia and polymicrobial sepsis J. Exp. Med., June 19, 2006; (2006) jem.20052362. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Perlik, Z. Li, S. Goorha, L. R. Ballou, and C. M. Blatteis LPS-activated complement, not LPS per se, triggers the early release of PGE2 by Kupffer cells Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2005; 289(2): R332 - R339. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Feleder, V. Perlik, and C. M. Blatteis Preoptic {alpha}1- and {alpha}2-noradrenergic agonists induce, respectively, PGE2-independent and PGE2-dependent hyperthermic responses in guinea pigs Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2004; 286(6): R1156 - R1166. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Feleder, Z. Li, V. Perlik, A. Evans, and C. M. Blatteis The spleen modulates the febrile response of guinea pigs to LPS Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2003; 284(6): R1466 - R1476. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. I. Ivanov, R. S. Pero, A. C. Scheck, and A. A. Romanovsky Prostaglandin E2-synthesizing enzymes in fever: differential transcriptional regulation Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2002; 283(5): R1104 - R1117. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Ledeboer, R. Binnekade, J. J. P. Breve, J. G. J. M. Bol, F. J. H. Tilders, and A.-M. Van Dam Site-specific modulation of LPS-induced fever and interleukin-1beta expression in rats by interleukin-10 Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2002; 282(6): R1762 - R1772. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Hosoi, Y. Okuma, A. Ono, and Y. Nomura Subdiaphragmatic vagotomy fails to inhibit intravenous leptin-induced IL-1beta expression in the hypothalamus Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2002; 282(2): R627 - R631. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. K. Hansen, K. A. O'Connor, L. E. Goehler, L. R. Watkins, and S. F. Maier The contribution of the vagus nerve in interleukin-1{beta}-induced fever is dependent on dose Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2001; 280(4): R929 - R934. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. E. Hermann, G. S. Emch, C. A. Tovar, and R. C. Rogers c-Fos generation in the dorsal vagal complex after systemic endotoxin is not dependent on the vagus nerve Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2001; 280(1): R289 - R299. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. M. Martin, B. C. Wilson, X. Chen, Y. Takahashi, P. Poulin, and Q. J. Pittman Vagal CCK and 5-HT3 receptors are unlikely to mediate LPS or IL-1beta -induced fever Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2000; 279(3): R960 - R965. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Hosoi, Y. Okuma, and Y. Nomura Electrical stimulation of afferent vagus nerve induces IL-1beta expression in the brain and activates HPA axis Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2000; 279(1): R141 - R147. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Li, E. Sehic, Y. Wang, A. L. Ungar, and C. M. Blatteis Relation between complement and the febrile response of guinea pigs to systemic endotoxin Am J Physiol Regulatory Integrative Comp Physiol, December 1, 1999; 277(6): R1635 - R1645. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. A. Romanovsky, A. I. Ivanov, and E. K. Karman Blood-borne, albumin-bound prostaglandin E2 may be involved in fever Am J Physiol Regulatory Integrative Comp Physiol, June 1, 1999; 276(6): R1840 - R1844. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. A. Romanovsky;, T. E. Scammell, J. K. Elmquist, and C. B. Saper Febrile nonresponsiveness of vagotomized animals: is it due to endotoxin translocation from the gut and tolerance? Am J Physiol Regulatory Integrative Comp Physiol, September 1, 1998; 275(3): R933 - R935. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
