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, LPS, and MDP
1 Institute for Animal Sciences, Physiology and Animal Husbandry, Swiss Federal Institute of Technology, 8092 Zurich, Switzerland; and 2 Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
We investigated the extrinsic gut neural
mediation of the suppression of food intake in male Sprague-Dawley rats
induced by peripheral intraperitoneal administration of 2 µg/kg
interleukin-1
(IL-1), 100 µg/kg bacterial
lipopolysaccharide (LPS), and 2 mg/kg muramyl dipeptide (MDP). Food
intake during the first 3 and 6 h of the dark cycle was measured in
rats with subdiaphragmatic vagal deafferentation
(n = 9), celiac superior mesenteric
ganglionectomy (n = 9), combined
vagotomy and ganglionectomy (n = 9),
and sham deafferentation (n = 9).
IL-1, LPS, and MDP suppressed food intake at 3 and 6 h in all
surgical groups. The results demonstrate that neither vagal nor
nonvagal afferent nerves from the upper gut are necessary for the
feeding-suppressive effects of intraperitoneal IL-1, LPS, or MDP in
the rat and suggest that peripheral administration of immunomodulators
produces anorexia via a humoral pathway.
interleukin-1; lipopolysaccharide; muramyl dipeptide; food
intake; brain-gut communication; cytokine; bacterial products
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