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Am J Physiol Regul Integr Comp Physiol 275: R466-R470, 1998;
0363-6119/98 $5.00
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Vol. 275, Issue 2, R466-R470, August 1998

Ontogeny of neuropeptide Y expression in response to deprivation in lean Zucker rat pups

Timothy J. Kowalski1, Thomas A. Houpt1, Jeongwon Jahng2, Nori Okada3, Streamson C. Chua Jr.3, and Gerard P. Smith1

1 E. W. Bourne Laboratory, New York Hospital-Cornell Medical Center; 2 Laboratory of Molecular Neurobiology, Burke Medical Research Institute, Department of Neurology and Neuroscience, White Plains 10605; and 3 Laboratory of Human Behavior and Metabolism, The Rockefeller University, New York, New York 10021

Hypothalamic neuropeptide Y (NPY) activity is believed to play an important role in the response to food deprivation in adult rats. Little is known, however, about the role of the hypothalamic NPY system in the control of food intake in the preweanling rat. To address this issue, we examined the effect of deprivation on arcuate nucleus preproNPY expression in lean Zucker rat pups, using in situ hybridization. PreproNPY expression within the arcuate nucleus was localized to cells in the medial portion. Twenty-four hours of food, water, and maternal deprivation significantly increased the relative abundance of preproNPY mRNA in pups on postnatal day (P) 2, P9, P12, and P15 by 14-31%. This response, however, was not observed on P5. The absence of an effect on P5 and the magnitude of the response at the other ages tested were not correlated with the amount of weight lost during deprivation.

in situ hybridization; arcuate nucleus; neonate; starvation


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