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Department of Cardiovascular Dynamics, The National Cardiovascular Center Research Institute, Suita, Osaka, Japan
Recent investigations in our laboratory
using a Gaussian white noise technique showed that the transfer
function representing the dynamic properties of transduction from vagus
nerve activity to heart rate had characteristics of a first-order
low-pass filter. However, the physiological determinants of those
characteristics remain to be elucidated. In this study, we stimulated
the vagus nerve according to a Gaussian white noise pattern to estimate the transfer function from vagal stimulation to the heart rate response
in anesthetized rabbits and examined how changes in acetylcholine kinetics affected the transfer function. We found that although increases in the mean frequency of vagal stimulation from 5 to 10 Hz
did not change the characteristics of the transfer function, administration of neostigmine (30 µg · kg
1 · h1
iv), a cholinesterase inhibitor, increased the dynamic gain from 8.19 ± 3.66 to 11.7 ± 4.88 beats · min1 · Hz1
(P < 0.05), decreased the corner
frequency from 0.12 ± 0.05 to 0.04 ± 0.01 Hz
(P < 0.01), and increased the lag
time from 0.17 ± 0.12 to 0.27 ± 0.08 s
(P < 0.05). These results suggest
that the rate of acetylcholine degradation at the neuroeffector
junction, rather than the amount of available acetylcholine, plays a
key role in determining the dynamic properties of transduction from vagus nerve activity to heart rate.
systems analysis; Gaussian white noise; dynamic stimulation; rabbit
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