| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1 Department of Kinesiology and Applied Physiology and 2 Department of Psychology, University of Colorado, Boulder, Colorado 80309
Acute stressor exposure alters immune
function. Rats exposed to inescapable tail shock stress (IS) generate
less antibody to a benign, antigenic protein, keyhole limpet hemocyanin
(KLH). The following studies examined the effect of IS on peritoneal cavity, spleen, and mesenteric lymph node cell number, interferon-
(IFN-) production, and nitrite production. Rats were injected intraperitoneally with KLH (200 µg) or saline immediately before IS
exposure and killed 0, 48, and 96 h after IS termination. KLH immunization resulted in elevated cell numbers and IFN- levels 2-4 days later in nonstressed control rats. In contrast, rats exposed to IS failed to increase cell number and IFN- levels in
response to KLH. The T cell subpopulations affected were CD4 T cells,
specifically the Th1-like subset. In addition, in rats exposed to IS + KLH, nitrite production was potentiated 2-4 days after stressor
termination. IS had little effect on these measures in saline-injected
rats. These data support the conclusion that exposure to IS suppresses
the expansion of anti-KLH lymphocytes, possibly anti-KLH Th1 cells. In
addition, stressor exposure potentiates the production of nitrite.
Importantly, this potentiated response occurred only in KLH-immunized
animals, suggesting that macrophages may be primed by stressor exposure
and thus respond more vigorously to antigen. The potential links
between these changes are discussed.
stress; Th1 cells; CD4 T cells; nitric oxide; keyhole limpet
hemocyanin; interferon-
This article has been cited by other articles:
|
|
 |
|
  M. T. Bailey, H. Engler, N. D. Powell, D. A. Padgett, and J. F. Sheridan Repeated social defeat increases the bactericidal activity of splenic macrophages through a Toll-like receptor-dependent pathway Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2007; 293(3): R1180 - R1190. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Yorty and R. H. Bonneau Impact of maternal stress on the transmammary transfer and protective capacity of herpes simplex virus-specific immunity Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2004; 287(6): R1316 - R1324. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Campisi,, M. K. Hansen,, K. A. O'Connor,, J. C. Biedenkapp,, L. R. Watkins,, S. F. Maier,, and M. Fleshner Circulating cytokines and endotoxin are not necessary for the activation of the sickness or corticosterone response produced by peripheral E. coli challenge J Appl Physiol, November 1, 2003; 95(5): 1873 - 1882. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. F. Elphick, J. Wieseler-Frank, B. N. Greenwood, J. Campisi, and M. Fleshner B-1 cell (CD5+/CD11b+) numbers and nIgM levels are elevated in physically active vs. sedentary rats J Appl Physiol, July 1, 2003; 95(1): 199 - 206. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. F. Elphick, B. N. Greenwood, J. Campisi, and M. Fleshner Increased serum nIgM in voluntarily physically active rats: a potential role for B-1 cells J Appl Physiol, February 1, 2003; 94(2): 660 - 667. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Campisi, T. H. Leem, B. N. Greenwood, M. K. Hansen, A. Moraska, K. Higgins, T. P. Smith, and M. Fleshner Habitual physical activity facilitates stress-induced HSP72 induction in brain, peripheral, and immune tissues Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2003; 284(2): R520 - R530. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Campisi and M. Fleshner Role of extracellular HSP72 in acute stress-induced potentiation of innate immunity in active rats J Appl Physiol, January 1, 2003; 94(1): 43 - 52. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Moraska, J. Campisi, K. T. Nguyen, S. F. Maier, L. R. Watkins, and M. Fleshner Elevated IL-1beta contributes to antibody suppression produced by stress J Appl Physiol, July 1, 2002; 93(1): 207 - 215. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Fleshner, J. Campisi, T. Deak, B. N. Greenwood, J. A. Kintzel, T. H. Leem, T. P. Smith, and B. Sorensen Acute stressor exposure facilitates innate immunity more in physically active than in sedentary rats Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2002; 282(6): R1680 - R1686. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. L. Shuster Jr., J. L. Shuster Jr., R. Murison, and M. Fleshner Handbook of Psychiatry in Palliative Medicine Crossing Over: Narratives of Palliative Care The Biological Basis of Mind-Body Interactions Cytokines, Stress, and Depression: Advances in Experimental Medicine and Biology Psychosom Med, May 1, 2001; 63(3): 511 - 515. [Full Text] [PDF]
|
|
|
|
|
|
A. Moraska, T. Deak, R. L. Spencer, D. Roth, and M. Fleshner Treadmill running produces both positive and negative physiological adaptations in Sprague-Dawley rats Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2000; 279(4): R1321 - R1329. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
