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Am J Physiol Regul Integr Comp Physiol 275: R913-R919, 1998;
0363-6119/98 $5.00
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Vol. 275, Issue 3, R913-R919, September 1998

Leptin causes body weight loss in the absence of in vivo activities typical of cytokines of the IL-6 family

Davide Agnello1, Cristina Meazza1, Christopher G. Rowan2, Pia Villa1, Pietro Ghezzi1,3, and Giorgio Senaldi2

1 "Mario Negri" Institute for Pharmacological Research, 20157 Milan, Italy; 2 Amgen, Thousand Oaks 91320, and 3 Department of Genetics, Stanford University, Stanford, California 94305

To investigate if leptin shares in vivo activities with interleukin (IL)-6 family cytokines, it was tested in normal mice for the ability, after a single injection, to induce the acute-phase protein serum amyloid A, to potentiate the induction by IL-1 of serum corticosterone and IL-6, and to inhibit the induction by lipopolysaccharide of serum tumor necrosis factor and, after seven daily injections, to cause body weight loss and to change peripheral blood cell counts. At a 0.5 mg/kg dose, leptin caused body weight loss but did not show any of the other activities above. At a dose of 5 mg/kg, which also caused body weight loss, leptin potentiated the induction by IL-1 of serum corticosterone and IL-6 but did not show any other activity. In addition to causing body weight loss, leptin shows only some of the in vivo activities typical of IL-6 family cytokines and only if used at a dose that exceeds the one sufficient to affect body weight. In vivo, leptin seems to chiefly control body weight and not inflammatory or hematopoietic processes.

corticosterone; interleukin-1; leukemia inhibitory factor; peripheral blood cells; tumor necrosis factor


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