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Am J Physiol Regul Integr Comp Physiol 275: R1058-R1065, 1998;
0363-6119/98 $5.00
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Vol. 275, Issue 4, R1058-R1065, October 1998

Alteration of renal function of rats following spaceflight

Charles E. Wade1,2 and Emily Morey-Holton1,3

1 National Aeronautics and Space Administration Ames Research Center, Moffett Field 94035; 2 University of California, Davis 95616; and 3 University of California, San Francisco, California 94143

Following spaceflight, changes in renal function of humans have been suggested. To assess the effects of readaptation on renal function, urine was collected from male rats (~245 g) over a 2-wk period following a 14-day spaceflight. Rats were assigned to three groups: flight animals (n = 6), flight controls (n = 6) housed in the flight cages on the ground, and vivarium controls (n = 5) housed in standard shoe box cages. Animals were placed into individual metabolic cages for urine collection. Urine output was significantly increased for 3 days following flight. Excretion rates of Na+ and K+ were increased, resulting in an increased osmotic excretion rate. Creatinine excretion rate increased over the first two postflight days. Glomerular filtration rate increased immediately following spaceflight without changes in plasma creatinine, Na+, K+, or osmolality. Increased excretion of solute was thus the result of increased delivery and a decreased percent reabsorption of the filtered load. Osmolal clearance was increased immediately postflight while free water clearance was decreased. In growing rats, the diuresis after short-duration spaceflight is the result of an increase in solute excretion with an accompanying reduction in free water clearance.

urinary sodium and potassium excretion; aldosterone; free water clearance; osmolal clearance


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