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Am J Physiol Regul Integr Comp Physiol 275: R1075-R1081, 1998;
0363-6119/98 $5.00
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Vol. 275, Issue 4, R1075-R1081, October 1998

Role of nitric oxide in adrenal catecholamine secretion in anesthetized dogs

Takahiro Nagayama1, Akio Hosokawa1, Makoto Yoshida1, Mizue Suzuki-Kusaba1, Hiroaki Hisa1, Tomohiko Kimura2, and Susumu Satoh1

1 Department of Pharmacology, Pharmaceutical Institute, Tohoku University, Aobayama, Sendai 980-8578; and 2 Department of Dental Pharmacology, The Nippon Dental University School of Dentistry at Niigata, Niigata 951-8580, Japan

We examined the role of nitric oxide (NO) in adrenal catecholamine secretion in response to splanchnic nerve stimulation (SNS) and exogenous acetylcholine (ACh) in anesthetized dogs. The NO synthase inhibitor Nomega -nitro-L-arginine methyl ester (L-NAME), NO donor 3-(2-hydroxy-1-methyl-2-nitrosohydrazino)-N-methyl-1-propanamine (NOC 7), and ACh were administered intra-arterially into the adrenal gland. The increases in catecholamine output induced by ACh (0.75-3 µg) were enhanced by L-NAME (0.1-1 mg/min) and inhibited by NOC 7 (0.2-2 µg/min). Inhibition by NOC 7 (2 µg/min) was observed during treatment with L-NAME (1 mg/min). The increases in catecholamine output induced by SNS (1-2 Hz) were inhibited by L-NAME and by NOC 7. No inhibitory effect of NOC 7 was observed during treatment with L-NAME. These results suggest that NO may play an inhibitory role in the regulation of adrenal catecholamine secretion in response to exogenous ACh.

adrenal gland; Nomega -nitro-L-arginine methyl ester; 3-(2-hydroxy-1-methyl-2-nitrosohydrazino)-N-methyl-1-propanamine; splanchnic nerve stimulation; acetylcholine


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