AJP - Regu Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 275: R1232-R1238, 1998;
0363-6119/98 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Boyer, B. B.
Right arrow Articles by Grujic, D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Boyer, B. B.
Right arrow Articles by Grujic, D.
Vol. 275, Issue 4, R1232-R1238, October 1998

Differential regulation of uncoupling protein gene homologues in multiple tissues of hibernating ground squirrels

Bert B. Boyer1, Brian M. Barnes1, Bradford B. Lowell2, and Danica Grujic2

1 Institute of Arctic Biology, University of Alaska Fairbanks, Fairbanks, Alaska 99775; and 2 Division of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215

Nonshivering thermogenesis in brown adipose tissue (BAT) provides heat through activation of a mitochondrial uncoupling protein (UCP1), which causes futile electron transport cycles without the production of ATP. Recent discovery of two molecular homologues, UCP2, expressed in multiple tissues, and UCP3, expressed in muscle, has resulted in investigation of their roles in thermoregulatory physiology and energy balance. To determine the expression pattern of Ucp homologues in hibernating mammals, we compared relative mRNA levels of Ucp1, -2, and -3 in BAT, white adipose tissue (WAT), and skeletal muscle of arctic ground squirrels (Spermophilus parryii) hibernating at different ambient and body temperatures, with levels determined in tissues from ground squirrels not in hibernation. Here we report significant increases in mRNA levels for Ucp2 in WAT (1.6-fold) and Ucp3 in skeletal muscle (3-fold) during hibernation. These results indicate the potential for a role of UCP2 and UCP3 in thermal homeostasis during hibernation and indicate that parallel mechanisms and multiple tissues could be important for nonshivering thermoregulation in mammals.

nonshivering thermogenesis; Spermophilus; uncoupling protein 1; uncoupling protein 2; uncoupling protein 3


This article has been cited by other articles:


Home page
 Physiol. GenomicsHome page
J. Yan, B. M. Barnes, F. Kohl, and T. G. Marr
Modulation of gene expression in hibernating arctic ground squirrels
Physiol Genomics, January 17, 2008; 32(2): 170 - 181.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. L. Barger, B. M. Barnes, and B. B. Boyer
Regulation of UCP1 and UCP3 in arctic ground squirrels and relation with mitochondrial proton leak
J Appl Physiol, July 1, 2006; 101(1): 339 - 347.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
N. J. Hudson, S. A. Lehnert, A. B. Ingham, B. Symonds, C. E. Franklin, and G. S. Harper
Lessons from an estivating frog: sparing muscle protein despite starvation and disuse
Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2006; 290(3): R836 - R843.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. ProteomicsHome page
L. E. Epperson, T. A. Dahl, and S. L. Martin
Quantitative Analysis of Liver Protein Expression During Hibernation in the Golden-mantled Ground Squirrel
Mol. Cell. Proteomics, September 1, 2004; 3(9): 920 - 933.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
H. V. CAREY, M. T. ANDREWS, and S. L. MARTIN
Mammalian Hibernation: Cellular and Molecular Responses to Depressed Metabolism and Low Temperature
Physiol Rev, October 1, 2003; 83(4): 1153 - 1181.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. GenomicsHome page
L. E. Epperson and S. L. Martin
Quantitative assessment of ground squirrel mRNA levels in multiple stages of hibernation
Physiol Genomics, August 14, 2002; 10(2): 93 - 102.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
F. van Breukelen and S. L. Martin
Molecular Biology of Thermoregulation: Invited Review: Molecular adaptations in mammalian hibernators: unique adaptations or generalized responses?
J Appl Physiol, June 1, 2002; 92(6): 2640 - 2647.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
G. Argyropoulos and M.-E. Harper
Molecular Biology of Thermoregulation: Invited Review: Uncoupling proteins and thermoregulation
J Appl Physiol, May 1, 2002; 92(5): 2187 - 2198.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. GenomicsHome page
C. R. VIANNA, T. HAGEN, C.-Y. ZHANG, E. BACHMAN, O. BOSS, B. GEREBEN, A. S. MORISCOT, B. B. LOWELL, J. E. P. W. BICUDO, and A. C. BIANCO
Cloning and functional characterization of an uncoupling protein homolog in hummingbirds
Physiol Genomics, April 2, 2001; 5(3): 137 - 145.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. GenomicsHome page
M. J. BUCK, T. L. SQUIRE, and M. T. ANDREWS
Coordinate expression of the PDK4 gene: a means of regulating fuel selection in a hibernating mammal
Physiol Genomics, February 11, 2002; 8(1): 5 - 13.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online