AJP - Regu Watch the video to learn how APS reaches out to developing nations.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 275: R1308-R1319, 1998;
0363-6119/98 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Meyer, J. H.
Right arrow Articles by Raybould, H. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Meyer, J. H.
Right arrow Articles by Raybould, H. E.
Vol. 275, Issue 4, R1308-R1319, October 1998

Length of intestinal contact on nutrient-driven satiety

J. H. Meyer, Y. Tabrizi, N. DiMaso, M. Hlinka, and H. E. Raybould

Departments of Physiology and Medicine, University of California Los Angeles School of Medicine and the West Los Angeles Veterans Affairs Medical Center, Los Angeles, California 90073

Chemosensors throughout small bowel and colon inhibit food intakes when contacted by monomeric nutrients. We postulated that calorie-dependent inhibition of food intakes depended on additions of feedbacks from sensors in proximal and distal bowel contacted after high intakes of nutrients. Therefore, we determined how feedback from sensors in proximal gut interacted with feedback from simultaneously contacted sensors in distal bowel and whether suppression of nutrient intakes by intestinally perfused nutrients depended on length of gut contacted. Suppression of food intakes by maltose simply added to that from dodecanoate when both were present together either in proximal or distal small bowel. When dodecanoate was infused into proximal gut while maltose was infused distally, suppression of intake was threefold higher and was thus potentiated. Limiting contact of slowly absorbed lactose or oleate to 35 cm of jejunum nearly abolished the satiating potencies each exhibited during access to whole gut. The observations were consistent with our hypothesis.

length of contact; load dependence; caloric equivalencies; intestinal integration


This article has been cited by other articles:


Home page
 Am. J. Clin. Nutr.Home page
K. L Feltrin, T. J Little, J. H Meyer, M. Horowitz, T. Rades, J. Wishart, and C. Feinle-Bisset
Comparative effects of intraduodenal infusions of lauric and oleic acids on antropyloroduodenal motility, plasma cholecystokinin and peptide YY, appetite, and energy intake in healthy men
Am. J. Clinical Nutrition, May 1, 2008; 87(5): 1181 - 1187.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
A. N. Pilichiewicz, P. Papadopoulos, I. M. Brennan, T. J. Little, J. H. Meyer, J. M. Wishart, M. Horowitz, and C. Feinle-Bisset
Load-dependent effects of duodenal lipid on antropyloroduodenal motility, plasma CCK and PYY, and energy intake in healthy men
Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2007; 293(6): R2170 - R2178.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
T. J Little, M. Horowitz, and C. Feinle-Bisset
Modulation by high-fat diets of gastrointestinal function and hormones associated with the regulation of energy intake: implications for the pathophysiology of obesity
Am. J. Clinical Nutrition, September 1, 2007; 86(3): 531 - 541.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
K. L. Feltrin, T. J. Little, J. H. Meyer, M. Horowitz, T. Rades, J. Wishart, and C. Feinle-Bisset
Effects of lauric acid on upper gut motility, plasma cholecystokinin and peptide YY, and energy intake are load, but not concentration, dependent in humans
J. Physiol., June 1, 2007; 581(2): 767 - 777.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
T. J. Little, S. Doran, J. H. Meyer, A. J. P. M. Smout, D. G. O'Donovan, K.-L. Wu, K. L. Jones, J. Wishart, C. K. Rayner, M. Horowitz, et al.
The release of GLP-1 and ghrelin, but not GIP and CCK, by glucose is dependent upon the length of small intestine exposed
Am J Physiol Endocrinol Metab, September 1, 2006; 291(3): E647 - E655.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
A. N. Pilichiewicz, T. J. Little, I. M. Brennan, J. H. Meyer, J. M. Wishart, B. Otto, M. Horowitz, and C. Feinle-Bisset
Effects of load, and duration, of duodenal lipid on antropyloroduodenal motility, plasma CCK and PYY, and energy intake in healthy men
Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2006; 290(3): R668 - R677.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
M. R. Hayes, R. L. Moore, S. M. Shah, and M. Covasa
5-HT3 receptors participate in CCK-induced suppression of food intake by delaying gastric emptying
Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2004; 287(4): R817 - R823.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
C. Feinle, D. O'Donovan, S. Doran, J. M. Andrews, J. Wishart, I. Chapman, and M. Horowitz
Effects of fat digestion on appetite, APD motility, and gut hormones in response to duodenal fat infusion in humans
Am J Physiol Gastrointest Liver Physiol, May 1, 2003; 284(5): G798 - G807.
[Abstract] [Full Text] [PDF]

Home page
 GutHome page
J H Meyer, A Lembo, J D Elashoff, R Fass, and E A Mayer
Duodenal fat intensifies the perception of heartburn
Gut, November 1, 2001; 49(5): 624 - 628.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
L. Marciani, P. A. Gowland, R. C. Spiller, P. Manoj, R. J. Moore, P. Young, and A. J. Fillery-Travis
Effect of meal viscosity and nutrients on satiety, intragastric dilution, and emptying assessed by MRI
Am J Physiol Gastrointest Liver Physiol, June 1, 2001; 280(6): G1227 - G1233.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
L. Marciani, P. A. Gowland, A. Fillery-Travis, P. Manoj, J. Wright, A. Smith, P. Young, R. Moore, and R. C. Spiller
Assessment of antral grinding of a model solid meal with echo-planar imaging
Am J Physiol Gastrointest Liver Physiol, May 1, 2001; 280(5): G844 - G849.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
T. A. Spiegel, H. Fried, C. D. Hubert, S. R. Peikin, J. A. Siegel, and L. S. Zeiger
Effects of posture on gastric emptying and satiety ratings after a nutritive liquid and solid meal
Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2000; 279(2): R684 - R694.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
C. K. Rayner, H. S. Park, J. M. Wishart, M.-F. Kong, S. M. Doran, and M. Horowitz
Effects of intraduodenal glucose and fructose on antropyloric motility and appetite in healthy humans
Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2000; 278(2): R360 - R366.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
C. K. Rayner, H. S. Park, S. M. Doran, I. M. Chapman, and M. Horowitz
Effects of cholecystokinin on appetite and pyloric motility during physiological hyperglycemia
Am J Physiol Gastrointest Liver Physiol, January 1, 2000; 278(1): G98 - G104.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
J. H. Meyer, M. Hlinka, Y. Tabrizi, N. DiMaso, and H. E. Raybould
Chemical specificities and intestinal distributions of nutrient-driven satiety
Am J Physiol Regulatory Integrative Comp Physiol, October 1, 1998; 275(4): R1293 - R1307.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
J. H. Meyer, M. Hlinka, A. Khatibi, H. E. Raybould, and P. Tso
Role of small intestine in caloric compensations to oil premeals in rats
Am J Physiol Regulatory Integrative Comp Physiol, October 1, 1998; 275(4): R1320 - R1333.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online