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Am J Physiol Regul Integr Comp Physiol 275: R1353-R1357, 1998;
0363-6119/98 $5.00
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Vol. 275, Issue 4, R1353-R1357, October 1998

Cytokine-induced fever in obese (fa/fa) and lean (Fa/Fa) Zucker rats

Carlos R. Plata-Salamán1,2, Elizabeth Peloso3, and Evelyn Satinoff2,3

Departments of 1 Biological Sciences and 3 Psychology and 2 Program in Neuroscience, University of Delaware, Newark, Delaware 19716-2590

In earlier work, we reported that genetically obese (fa/fa) Zucker rats exhibited significantly greater anorexia than did lean (Fa/Fa) Zucker rats to intracerebroventricular infusion of interleukin (IL)-1beta . Here, we investigated the fever response of obese (fa/fa) and lean (Fa/Fa) Zucker rats to intracerebroventricular microinfusion of IL-1beta as well as to the following other cytokines: IL-2, IL-6, and tumor necrosis factor-alpha (TNF-alpha ). Core body temperature was monitored by a radiotelemetry system in freely moving rats. The results show that 1) both IL-1beta and IL-6 induce fevers in obese and lean rats; 2) IL-1beta induces a significantly higher fever response in obese rats than it does in lean rats; 3) IL-6 induces a significantly higher fever response in lean rats than it does in obese rats; 4) IL-2 induces a moderate fever response in lean but not obese rats; 5) TNF-alpha induces a similar fever response in obese and lean rats; and 6) the fevers induced by each effective cytokine have different time courses. Thus obese (fa/fa) and lean (Fa/Fa) Zucker rats show differential responsiveness to the intracerebroventricular microinfusion of various classes of cytokines. This suggests that genetic obesity in the fa/fa Zucker rat is associated with differential cytokine action on thermoregulatory mechanisms.

interleukin; tumor necrosis factor; intracerebroventricular; core temperature; nervous system; immune system


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