| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
2 Departments of Psychology and Pharmacology and the Cardiovascular Center, University of Iowa, Iowa City, Iowa 52242-1407; and 1 Departamento de Ciências Fisiológicas, Faculdade de Odontologia, Paulista State University, Araraquara, São Paulo 14801-903, Brazil
The
present study investigated the effects of bilateral injections of the
nonselective CCK receptor antagonist proglumide or CCK-8
into the lateral parabrachial nuclei (LPBN) on the ingestion of 0.3 M
NaCl and water induced by intracerebroventricular
injection of ANG II or by a combined treatment with subcutaneous
furosemide (Furo) + captopril (Cap). Compared with the
injection of saline (vehicle), bilateral LPBN injections of proglumide
(50 µg · 200 nl
1 · site1)
increased the intake of 0.3 M NaCl induced by intracerebroventricular ANG II (50 ng/1 µl). Bilateral injections of proglumide into the LPBN
also increased ANG II-induced water intake when NaCl was simultaneously
available, but not when only water was present. Similarly, the
ingestion of 0.3 M NaCl and water induced by the treatment with Furo
(10 mg/kg) + Cap (5 mg/kg) was increased by bilateral LPBN proglumide
pretreatment. Bilateral CCK-8 (0.5 µg · 200 nl1 · site1)
injections into the LPBN did not change Furo + Cap-induced
0.3 M NaCl intake but reduced water consumption. When only water was available after intracerebroventricular ANG II, bilateral LPBN injections of proglumide or CCK-8 had no effect or significantly reduced water intake compared with LPBN vehicle-treated rats. Taken
together, these results suggest that CCK actions in the LPBN play a
modulatory role on the control of NaCl and water intake induced by
experimental treatments that induce hypovolemia and/or hypotension or that mimic those states.
sodium chloride intake; water intake; proglumide; sodium appetite
This article has been cited by other articles:
|
|
 |
|
  J. I. F. De Gobbi, J. V. Menani, T. G. Beltz, R. F. Johnson, R. L. Thunhorst, and A. K. Johnson Right atrial stretch alters fore- and hind-brain expression of c-fos and inhibits the rapid onset of salt appetite J. Physiol., August 1, 2008; 586(15): 3719 - 3729. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. C. Geerling and A. D. Loewy Central regulation of sodium appetite Exp Physiol, February 1, 2008; 93(2): 177 - 209. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. De Castro e Silva, J. B. Fregoneze, and A. K. Johnson Corticotropin-releasing hormone in the lateral parabrachial nucleus inhibits sodium appetite in rats Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2006; 290(4): R1136 - R1141. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. V. Menani, S. P. Barbosa, L. A. De Luca Jr., J. I. F. De Gobbi, and A. K. Johnson Serotonergic mechanisms of the lateral parabrachial nucleus and cholinergic-induced sodium appetite Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2002; 282(3): R837 - R841. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. I. Fratucci De Gobbi, L. A. De Luca Jr., A. K. Johnson, and J. V. Menani Interaction of serotonin and cholecystokinin in the lateral parabrachial nucleus to control sodium intake Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2001; 280(5): R1301 - R1307. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
