| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Department of Pharmacology, The University of Texas Health Science Center, San Antonio, Texas 78284-7764
Animals with bilateral cannulas in the paraventricular nucleus were made hypertensive by a one-kidney, figure eight renal wrap procedure or sham operated. Femoral artery and vein catheters were inserted for arterial pressure measurement and plasma catecholamine determination. After recovery and 4 days after hypertension surgery, bicuculline methiodide or muscimol was microinjected into the paraventricular nucleus. In some rats, nitroprusside was infused intravenously to reflexly stimulate the sympathetic nervous system. In control rats, bicuculline increased blood pressure, heart rate, and plasma norepinephrine and epinephrine concentrations. In contrast, in hypertensive rats blood pressure did not change while the heart rate response was maintained. Plasma norepinephrine and epinephrine responses were reduced 75 and 68%, respectively. Muscimol injections decreased arterial pressure in the hypertensive rats. Heart rate responses to nitroprusside were similar in the two groups of rats, while the plasma catecholamine responses were attenuated in the hypertensive animals. These data suggest that GABA function in the paraventricular nucleus is reduced in renal wrap hypertension.
bicuculline; plasma catecholamines; paraventricular nucleus
This article has been cited by other articles:
|
|
 |
|
  F. Chen, M. Dworak, Y. Wang, J. L. Cham, and E. Badoer Role of the hypothalamic PVN in the reflex reduction in mesenteric blood flow elicited by hyperthermia Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2008; 295(6): R1874 - R1881. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Maliszewska-Scislo, H. Chen, R. A. Augustyniak, D. Seth, and N. F. Rossi Subfornical organ differentially modulates baroreflex function in normotensive and two-kidney, one-clip hypertensive rats Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2008; 295(3): R741 - R750. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D.-P. Li, Q. Yang, H.-M. Pan, and H.-L. Pan Plasticity of pre- and postsynaptic GABAB receptor function in the paraventricular nucleus in spontaneously hypertensive rats Am J Physiol Heart Circ Physiol, August 1, 2008; 295(2): H807 - H815. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. M. Sonner, J. A. Filosa, and J. E. Stern Diminished A-type potassium current and altered firing properties in presympathetic PVN neurones in renovascular hypertensive rats J. Physiol., March 15, 2008; 586(6): 1605 - 1622. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. B. Park, S. Skalska, S. Son, and J. E. Stern Dual GABAA receptor-mediated inhibition in rat presympathetic paraventricular nucleus neurons J. Physiol., July 15, 2007; 582(2): 539 - 551. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D.-P. Li and H.-L. Pan Plasticity of GABAergic control of hypothalamic presympathetic neurons in hypertension Am J Physiol Heart Circ Physiol, March 1, 2006; 290(3): H1110 - H1119. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Vitela, M. Herrera-Rosales, J. R. Haywood, and S. W. Mifflin Baroreflex regulation of renal sympathetic nerve activity and heart rate in renal wrap hypertensive rats Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2005; 288(4): R856 - R862. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. D. Stocker, K. J. Keith, and G. M. Toney Acute inhibition of the hypothalamic paraventricular nucleus decreases renal sympathetic nerve activity and arterial blood pressure in water-deprived rats Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2004; 286(4): R719 - R725. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q. H. Chen and G. M. Toney Responses to GABA-A receptor blockade in the hypothalamic PVN are attenuated by local AT1 receptor antagonism Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2003; 285(5): R1231 - R1239. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Q. H. Chen, J. R. Haywood, and G. M. Toney Sympathoexcitation by PVN-Injected Bicuculline Requires Activation of Excitatory Amino Acid Receptors Hypertension, October 1, 2003; 42(4): 725 - 731. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. E. De Wardener The Hypothalamus and Hypertension Physiol Rev, October 1, 2001; 81(4): 1599 - 1658. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Kenney, M. L. Weiss, K. P. Patel, Y. Wang, and R. J. Fels Paraventricular nucleus bicuculline alters frequency components of sympathetic nerve discharge bursts Am J Physiol Heart Circ Physiol, September 1, 2001; 281(3): H1233 - H1241. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. P. Fontes, T. Tagawa, J. W. Polson, S.-J. Cavanagh, and R. A. L. Dampney Descending pathways mediating cardiovascular response from dorsomedial hypothalamic nucleus Am J Physiol Heart Circ Physiol, June 1, 2001; 280(6): H2891 - H2901. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
