AJP - Regu Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 275: R1537-R1542, 1998;
0363-6119/98 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Arnelo, U.
Right arrow Articles by Permert, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Arnelo, U.
Right arrow Articles by Permert, J.
Vol. 275, Issue 5, R1537-R1542, November 1998

Sufficiency of postprandial plasma levels of islet amyloid polypeptide for suppression of feeding in rats

Urban Arnelo1,2, Roger Reidelberger1,3, Thomas E. Adrian1, Jörgen Larsson2, and Johan Permert2

1 Department of Biomedical Sciences, Creighton University School of Medicine, Omaha 68178; 2 Arvid Wretlind Laboratory for Metabolic Research, Department of Surgery, Karolinska Institutet at Huddinge University Hospital, S-14186 Huddinge, Sweden; and 3 Department of Veteran Affairs Medical Center, Omaha, Nebraska 68105

Our objective was to study whether islet amyloid polypeptide (IAPP) produces satiety by an endocrine mechanism. We used a rat model to determine whether postprandial plasma levels of IAPP are comparable to those required to inhibit feeding when IAPP is administered by continuous intravenous infusion. Food intake in rats with aortic catheters increased plasma IAPP levels from a fasting level of 10.8 ± 0.5 pM to a peak level of 19.0 ± 1.0 pM at 2.2 ± 0.5 h. In rats with jugular vein and aortic catheters, the threshold intravenous dose for IAPP suppression of feeding was between 1 and 3 pmol · kg-1 · min-1. The 3 pmol · kg-1 · min-1 dose decreased 4-h intake by ~25% by decreasing meal frequency rather than meal size. This dose increased plasma IAPP by ~24 pM. These results suggest that postprandial plasma levels of IAPP are not quite sufficient to independently produce satiety.

amylin; appetite regulation; meal patterns; radioimmunoassay; threshold dose


This article has been cited by other articles:


Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
R. D. Reidelberger, A. C. Haver, U. Arnelo, D. D. Smith, C. S. Schaffert, and J. Permert
Amylin receptor blockade stimulates food intake in rats
Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2004; 287(3): R568 - R574.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
T. Riediger, H. A. Schmid, T. Lutz, and E. Simon
Amylin potently activates AP neurons possibly via formation of the excitatory second messenger cGMP
Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2001; 281(6): R1833 - R1843.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
R. D. Reidelberger, U. Arnelo, L. Granqvist, and J. Permert
Comparative effects of amylin and cholecystokinin on food intake and gastric emptying in rats
Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2001; 280(3): R605 - R611.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
R. D. Reidelberger, L. Kelsey, and D. Heimann
Effects of amylin-related peptides on food intake, meal patterns, and gastric emptying in rats
Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2002; 282(5): R1395 - R1404.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online