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Am J Physiol Regul Integr Comp Physiol 275: R1543-R1552, 1998;
0363-6119/98 $5.00
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Vol. 275, Issue 5, R1543-R1552, November 1998

Responses of mesenteric and renal blood flow dynamics to acute denervation in anesthetized rats

Isam Abu-Amarah1, David O. Ajikobi1, Hélène Bachelard2, William A. Cupples1,3, and Fred C. Salevsky4

1 Lady Davis Institute and 3 Division of Nephrology, Department of Medicine, SMBD-Jewish General Hospital, Montreal H3T 1E2; 2 Unité de Recherche sur l'Hypertension, Centre Hospitalier de l'Université Laval, Laval G1V 4G2; and 4 Department of Anesthesiology, Montreal Neurological Hospital and Institute, Montreal, Quebec, Canada H3A 2B4

Previous studies have shown that renal autoregulation dynamically stabilizes renal blood flow (RBF). The role of renal nerves, particularly of a baroreflex component, in dynamic regulation of RBF remains unclear. The relative roles of autoregulation and mesenteric nerves in dynamic regulation of blood flow in the superior mesenteric artery (MBF) are similarly unclear. In this study, transfer function analysis was used to identify autoregulatory and baroreflex components in the dynamic regulation of RBF and MBF in Wistar rats and young spontaneously hypertensive rats (SHR) anesthetized with isoflurane or halothane. Wistar rats showed effective dynamic autoregulation of both MBF and RBF, as did SHR. Autoregulation was faster in the kidney (0.22 ± 0.01 Hz) than in the gut (0.13 ± 0.01 Hz). In the mesenteric, but not the renal bed, the admittance phase was significantly negative between 0.25 and 0.7 Hz, and the negative phase was abrogated by mesenteric denervation, indicating the presence of an arterial baroreflex. The baroreflex was faster than autoregulation in either bed. The presence of sympathetic effects unrelated to blood pressure was inferred in both vascular beds and appeared to be stronger in the SHR than in the Wistar rats. It is concluded that a physiologically significant baroreflex operates on the mesenteric, but not the renal circulation and that blood flow in both beds is effectively stabilized by autoregulation.

transfer function; Wistar rats; spontaneously hypertensive rats; autoregulation; baroreflex


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