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Ocean Research Institute, The University of Tokyo, Minamidai, Nakano, Tokyo 164, Japan
The
effects of eel atrial natriuretic peptide (ANP) on drinking were
investigated in eels adapted to freshwater (FW) or seawater (SW) or in
FW eels whose drinking was stimulated by a 2-ml hemorrhage. An
intra-arterial infusion of ANP (0.3-3.0
pmol · kg
1 · min1), which increased
plasma ANP level 1.5- to 20-fold, inhibited drinking dose dependently
in all groups of eels. The drinking rate recovered to the level before
ANP infusion within 2 h after infusate was replaced by saline. The
inhibition at 3.0 pmol · kg1 · min1
was profound in FW eels and hemorrhaged FW eels, whereas significant drinking still remained after inhibition in SW eels. Plasma ANG II
concentration also decreased dose dependently during ANP infusion and
recovered to the initial level after saline infusion in all groups of
eels. The decrease at 3.0 pmol · kg1 · min1
was large in FW eels and hemorrhaged FW eels compared with that of SW
eels. Thus the changes in drinking rate and plasma ANG II level were
parallel during ANP infusion. Plasma sodium concentration and
osmolality decreased during ANP infusion in SW and FW eels, and they
were restored after saline infusion. In hemorrhaged FW eels, however,
ANP infusion did not alter plasma sodium concentration and osmolality.
Hematocrit did not change during ANP infusion in any group of eels.
Collectively, ANP infusion at physiological doses decreased drinking
rate and plasma ANG II concentration in parallel in both FW and SW
eels. It remains undetermined whether the inhibition of drinking is
caused by direct action of ANP or through inhibition of ANG II, which
is known as a potent dipsogen in all vertebrate species, including
eels.
water intake; Anguilla japonica
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