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1 Southwest Foundation for Biomedical Research, San Antonio, Texas 78245-0549; 3 Howard Florey Institute and 2 Department of Physiology, University of Melbourne, Parkville, Victoria 3052, Australia
The roles of ANG II in the brain
mechanisms subserving thirst and Na appetite in baboons were
investigated by chronic intracerebroventricular infusions of ANG II and
AT1-receptor antagonists using
subcutaneous miniosmotic pumps and by oral administration of captopril.
ANG II at 3 or 5 µg/h for 7 days increased water intake from 2,455 ± 107 to 7,052 ± 562 ml/day by day
6 and 300 mM NaCl intake from 8.3 ± 1.1 to 275 ± 87 mmol/day by day 5. Concurrent
intracerebroventricular losartan (300 µg/h) did not substantially
reduce these responses, but they were abolished by
intracerebroventricular ZD-7155 (50 µg/h). The increase of 300 mM
NaCl intake when it was offered after intramuscular injection of
furosemide, 2 mg · kg
1 · day1
for 3 days, was unaltered by intracerebroventricular losartan (300 µg/h) but was reduced by intracerebroventricular ZD-7155 (50 µg/h)
infused throughout Na depletion/repletion; oral captopril (1 g, 3 and
18 h before access to 300 mM NaCl) also reduced NaCl intake.
Restriction of water intake to 25% of daily intake for 3 days caused a
high intake of water on day 4, and
this was reduced by intracerebroventricular losartan (300 µg/h)
infused throughout the period of water restriction/rehydration. These
novel results in a primate species suggest that brain ANG II is
involved in both thirst and Na appetite, acting via
AT1 receptors.
angiotensin receptors; nonhuman primate; losartan; sodium appetite; ZD-7155; captopril
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