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Am J Physiol Regul Integr Comp Physiol 275: R1719-R1723, 1998;
0363-6119/98 $5.00
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Vol. 275, Issue 5, R1719-R1723, November 1998

SPECIAL COMMUNICATION
Hypertensive response to chronic NO synthase inhibition is different in Sprague-Dawley rats from two suppliers

David M. Pollock and Anthony Rekito

Vascular Biology Center, Department of Surgery and Department of Physiology and Endocrinology, Medical College of Georgia, Augusta, Georgia 30912-2500

Experiments were conducted to determine whether Sprague-Dawley rats from different suppliers have the same hypertensive response to chronic inhibition of nitric oxide synthase. Rats (240-260 g) obtained from either Harlan or Charles River Laboratories were maintained in metabolic cages for baseline (week 0) measurements before receiving Nomega -nitro-L-arginine methyl ester (L-NAME) in the drinking water for 2 wk at 5 or 65 mg · kg-1 · day-1. Baseline values for tail cuff pressure (TCP) were significantly higher in Harlan rats (131 ± 2 mmHg) compared with Charles River rats (108 ± 3 mmHg, P < 0.001). At 65 mg · kg-1 · day-1, L-NAME produced a significantly larger increase in TCP in Harlan versus Charles River rats (41 ± 4 vs. 29 ± 4%, respectively, P < 0.01). Food and water intake and sodium and water excretion were not different between groups. Urinary excretion of nitrate and nitrite (UNOxV) was significantly reduced in all rats given L-NAME. UNOxV was decreased by 69 ± 12 and 62 ± 7% in Harlan and Charles River rats, respectively. The lower dose of L-NAME increased TCP and decreased UNOxV in both Harlan and Charles River rats; these effects were more pronounced in the Harlan rats. These results suggest that NO plays a more significant role in the maintenance of arterial pressure in Sprague-Dawley rats from Harlan compared with Charles River Laboratories. Such findings may also provide insight as to why some of the mechanisms associated with chronic L-NAME treatment are not consistent between laboratories.

Nomega -nitro-L-arginine methyl ester; urinary nitrate and nitrite


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