AJP - Regu Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 275: R1968-R1976, 1998;
0363-6119/98 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Sharkey, L. C.
Right arrow Articles by Radin, M. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sharkey, L. C.
Right arrow Articles by Radin, M. J.
Vol. 275, Issue 6, R1968-R1976, December 1998

Effect of ovariectomy in heart failure-prone SHHF/Mcc-facp rats

Leslie C. Sharkey1, Bethany J. Holycross2, Sonhee Park3, Sylvia A. McCune3, Roger Hoversland4, and M. Judith Radin1

Departments of 1 Veterinary Biosciences, 2 Medical Biochemistry, and 3 Food Science and Technology, The Ohio State University, Columbus, Ohio 43210; and 4 Department of Anatomy, Indiana University School of Medicine, Fort Wayne, Indiana 46800

The importance of the loss of ovarian function to the progression of hypertension and heart disease in women is controversial. We investigated whether ovariectomy would accelerate development of hypertension, congestive heart failure, and neurohumoral activation in adult spontaneous hypertension heart failure (SHHF) rats, a genetic model of heart failure. Six months after ovariectomy, no significant differences between control and ovariectomized rats were seen in systolic or diastolic blood pressure, left ventricular fractional shortening by echocardiography, or heart weight. Percent V1 myosin isozyme was significantly lower in ovariectomized rats. Northern blot analysis failed to show significant differences between groups in expression of hepatic angiotensinogen, renal renin, or left ventricular atrial or brain natriuretic peptide mRNA. In a second experiment, serial measures of systolic pressure and left ventricular shortening fractions failed to document a significant difference between control and ovariectomized rats as they developed heart failure, although there was a significant decline in shortening fraction in both groups at the age when regular estrous cycling naturally ceases. Survival time was similar between groups. In summary, ovariectomy of adult SHHF rats does not appear to affect the progression of genetically programmed hypertension and heart failure in this model.

hypertension; shortening fraction; atrial natriuretic peptide; renin-angiotensin system; heart failure


This article has been cited by other articles:


Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
A. L. Chancey, J. D. Gardner, D. B. Murray, G. L. Brower, and J. S. Janicki
Modulation of cardiac mast cell-mediated extracellular matrix degradation by estrogen
Am J Physiol Heart Circ Physiol, July 1, 2005; 289(1): H316 - H321.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. J. Radin, B. J. Holycross, L. C. Sharkey, L. Shiry, and S. A. McCune
Gender modulates activation of renin-angiotensin and endothelin systems in hypertension and heart failure
J Appl Physiol, March 1, 2002; 92(3): 935 - 940.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
E. K. Jackson, C. K. Kost Jr., W. A. Herzer, G. J. Smits, and S. P. Tofovic
A1 Receptor Blockade Induces Natriuresis with a Favorable Renal Hemodynamic Profile in SHHF/Mcc-facp Rats Chronically Treated with Salt and Furosemide
J. Pharmacol. Exp. Ther., December 1, 2001; 299(3): 978 - 987.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online