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Am J Physiol Regul Integr Comp Physiol 275: R2035-R2042, 1998;
0363-6119/98 $5.00
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Vol. 275, Issue 6, R2035-R2042, December 1998

Multiple receptor subtypes mediate the effects of serotonin on rat subfornical organ neurons

Karie E. Scrogin1, Alan Kim Johnson1, and Herbert A. Schmid2

1 Departments of Psychology and Pharmacology and the Cardiovascular Center, University of Iowa, Iowa City, Iowa 52242; and 2 The Max-Planck-Institut für Physiologische und Klinische Forschung, W. G. Kerckhoff-Institut, 61231 Bad Nauheim, Germany

The subfornical organ (SFO) receives significant serotonergic innervation. However, few reports have examined the functional effects of serotonin on SFO neurons. This study characterized the effects of serotonin on spontaneously firing SFO neurons in the rat brain slice. Of 31 neurons tested, 80% responded to serotonin (1-100 µM) with either an increase (n = 15) or decrease (n = 10) in spontaneous activity. Responses to serotonin were dose dependent and persisted after synaptic blockade. Excitatory responses could also be mimicked by the 5-hydroxytryptamine (5-HT)2A/2C receptor agonist 2,5-dimethoxy-4-iodoamphetamine (DOI; 1-10 µM) and could be blocked by the 5-HT2A/2C-receptor antagonist LY-53,857 (10 µM). LY-53,857 unmasked inhibitory responses to serotonin in 56% of serotonin-excited cells tested. Serotonin-inhibited cells were also inhibited by the 5-HT1A-receptor agonist 8-hydroxy-2(di-n-propylamino)tetralin (8-OH-DPAT; 1-10 µM; n = 7). The data indicate that SFO neurons are responsive to serotonin via postsynaptic activation of multiple receptor subtypes. The results suggest that excitatory responses to serotonin are mediated by 5-HT2A or 5-HT2C receptors and that inhibitory responses may be mediated by 5-HT1A receptors. In addition, similar percentages of serotonin-excited and -inhibited cells were also sensitive to ANG II. As such the functional relationship between serotonin and ANG II in the SFO remains unclear.

5-hydroxytryptamine types 1A and 2A/2C; LY-53,857; 2,5-dimethoxy-4-iodoamphetamine; 8-hydroxy-2(di-n-propylamino)tetralin


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