AJP - Regu Ad Instruments
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 275: R2035-R2042, 1998;
0363-6119/98 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Scrogin, K. E.
Right arrow Articles by Schmid, H. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Scrogin, K. E.
Right arrow Articles by Schmid, H. A.
Vol. 275, Issue 6, R2035-R2042, December 1998

Multiple receptor subtypes mediate the effects of serotonin on rat subfornical organ neurons

Karie E. Scrogin1, Alan Kim Johnson1, and Herbert A. Schmid2

1 Departments of Psychology and Pharmacology and the Cardiovascular Center, University of Iowa, Iowa City, Iowa 52242; and 2 The Max-Planck-Institut für Physiologische und Klinische Forschung, W. G. Kerckhoff-Institut, 61231 Bad Nauheim, Germany

The subfornical organ (SFO) receives significant serotonergic innervation. However, few reports have examined the functional effects of serotonin on SFO neurons. This study characterized the effects of serotonin on spontaneously firing SFO neurons in the rat brain slice. Of 31 neurons tested, 80% responded to serotonin (1-100 µM) with either an increase (n = 15) or decrease (n = 10) in spontaneous activity. Responses to serotonin were dose dependent and persisted after synaptic blockade. Excitatory responses could also be mimicked by the 5-hydroxytryptamine (5-HT)2A/2C receptor agonist 2,5-dimethoxy-4-iodoamphetamine (DOI; 1-10 µM) and could be blocked by the 5-HT2A/2C-receptor antagonist LY-53,857 (10 µM). LY-53,857 unmasked inhibitory responses to serotonin in 56% of serotonin-excited cells tested. Serotonin-inhibited cells were also inhibited by the 5-HT1A-receptor agonist 8-hydroxy-2(di-n-propylamino)tetralin (8-OH-DPAT; 1-10 µM; n = 7). The data indicate that SFO neurons are responsive to serotonin via postsynaptic activation of multiple receptor subtypes. The results suggest that excitatory responses to serotonin are mediated by 5-HT2A or 5-HT2C receptors and that inhibitory responses may be mediated by 5-HT1A receptors. In addition, similar percentages of serotonin-excited and -inhibited cells were also sensitive to ANG II. As such the functional relationship between serotonin and ANG II in the SFO remains unclear.

5-hydroxytryptamine types 1A and 2A/2C; LY-53,857; 2,5-dimethoxy-4-iodoamphetamine; 8-hydroxy-2(di-n-propylamino)tetralin


This article has been cited by other articles:


Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
A. Godino, L. A. De Luca Jr., J. Antunes-Rodrigues, and L. Vivas
Oxytocinergic and serotonergic systems involvement in sodium intake regulation: satiety or hypertonicity markers?
Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2007; 293(3): R1027 - R1036.
[Abstract] [Full Text] [PDF]

Home page
 Exp PhysiolHome page
A. P. de Magalhaes-Nunes, D. Badaue-Passos Jr, R. R. Ventura, D. da Silva Guedes Jr, J. P. Araujo, P. C. Granadeiro, H. K. Milanez-Barbosa, R. H. da Costa-e-Sousa, M. A. de Medeiros, J. Antunes-Rodrigues, et al.
Neuroendocrinology/Endocrinology: Sertraline, a selective serotonin reuptake inhibitor, affects thirst, salt appetite and plasma levels of oxytocin and vasopressin in rats
Exp Physiol, September 1, 2007; 92(5): 913 - 922.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online