AJP - Regu Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 276: R136-R142, 1999;
0363-6119/99 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Faggioni, R.
Right arrow Articles by Grunfeld, C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Faggioni, R.
Right arrow Articles by Grunfeld, C.
Vol. 276, Issue 1, R136-R142, January 1999

Leptin deficiency enhances sensitivity to endotoxin-induced lethality

Raffaella Faggioni1, Giamila Fantuzzi2, Cem Gabay3, Arthur Moser1, Charles A. Dinarello2, Kenneth R. Feingold1, and Carl Grunfeld1

1 Metabolism Section, Department of Veterans Affairs Medical Center, University of California, San Francisco, California 94121; and Divisions of 2 Infectious Diseases and 3 Rheumatology, University of Colorado Health Sciences Center, Denver, Colorado 80262

Leptin is induced by lipopolysaccharide (LPS) and cytokines. We investigated the role of leptin in LPS-induced toxicity using leptin-deficient (ob/ob) and leptin receptor-deficient (db/db) mice. Sensitivity to LPS-induced mortality is significantly greater in ob/ob mice compared with their own lean littermates but not in db/db mice. LPS reduced serum glucose in both ob/ob and db/db mice but induced corticosterone only in db/db mice. Despite the very high basal levels of serum leptin in db/db mice, a twofold increase in serum leptin levels was observed after LPS in both db/db mice and their lean littermates. No differences were detected in LPS-induced serum levels of interleukin (IL)-1beta , tumor necrosis factor, macrophage inflammatory protein-1alpha , and interferon-gamma in ob/ob mice compared with their own littermates. In contrast, a blunted induction of IL-10 and IL-1 receptor antagonist (IL-1Ra) was observed in ob/ob mice compared with their littermates. In vitro, leptin induced IL-1Ra production and upregulated the IL-1Ra induction by LPS in macrophages. Moreover, treatment with leptin reversed the increased sensitivity to LPS-induced lethality found in ob/ob mice. These results suggest that leptin participates in the host response to inflammation by modulating the host immune and cytokine responses after LPS.

lipopolysaccharide; bacterial product; OB protein; leptin receptor; interleukin; tumor necrosis factor; macrophage inflammatory protein; cytokine


This article has been cited by other articles:


Home page
 J. Immunol.Home page
R. W. Hick, A. L. Gruver, M. S. Ventevogel, B. F. Haynes, and G. D. Sempowski
Leptin Selectively Augments Thymopoiesis in Leptin Deficiency and Lipopolysaccharide-Induced Thymic Atrophy
J. Immunol., July 1, 2006; 177(1): 169 - 176.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
J. W. Bullen Jr, M. Ziotopoulou, L. Ungsunan, J. Misra, I. Alevizos, E. Kokkotou, E. Maratos-Flier, G. Stephanopoulos, and C. S. Mantzoros
Short-term resistance to diet-induced obesity in A/J mice is not associated with regulation of hypothalamic neuropeptides
Am J Physiol Endocrinol Metab, October 1, 2004; 287(4): E662 - E670.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
A. M. Madiehe, T. D. Mitchell, and R. B. S. Harris
Hyperleptinemia and reduced TNF-alpha secretion cause resistance of db/db mice to endotoxin
Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2003; 284(3): R763 - R770.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Interv.Home page
B. J. Holycross and M. J. Radin
Cytokines in Heart Failure: Potential Interactions with Angiotensin II and Leptin
Mol. Interv., November 1, 2002; 2(7): 424 - 427.
[Abstract] [Full Text]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
P. B. Persson
What is written, read, and cited in AJP-Regulatory, Integrative and Comparative Physiology?
Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2002; 282(5): R1261 - R1263.
[Full Text] [PDF]

Home page
 J. Immunol.Home page
P. Mancuso, A. Gottschalk, S. M. Phare, M. Peters-Golden, N. W. Lukacs, and G. B. Huffnagle
Leptin-Deficient Mice Exhibit Impaired Host Defense in Gram-Negative Pneumonia
J. Immunol., April 15, 2002; 168(8): 4018 - 4024.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
N. Busso, A. So, V. Chobaz-Peclat, C. Morard, E. Martinez-Soria, D. Talabot-Ayer, and C. Gabay
Leptin Signaling Deficiency Impairs Humoral and Cellular Immune Responses and Attenuates Experimental Arthritis
J. Immunol., January 15, 2002; 168(2): 875 - 882.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
A. M. Diehl
Nonalcoholic Steatosis and Steatohepatitis: IV. Nonalcoholic fatty liver disease abnormalities in macrophage function and cytokines
Am J Physiol Gastrointest Liver Physiol, January 1, 2002; 282(1): G1 - G5.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
R. FAGGIONI, K. R. FEINGOLD, and C. GRUNFELD
Leptin regulation of the immune response and the immunodeficiency of malnutrition
FASEB J, December 1, 2001; 15(14): 2565 - 2571.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
C. Barazzone-Argiroffo, P. Muzzin, Y. R. Donati, C.-D. Kan, M. L. Aubert, and P.-F. Piguet
Hyperoxia increases leptin production: a mechanism mediated through endogenous elevation of corticosterone
Am J Physiol Lung Cell Mol Physiol, November 1, 2001; 281(5): L1150 - L1156.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
H. Zarkesh-Esfahani, G. Pockley, R. A. Metcalfe, M. Bidlingmaier, Z. Wu, A. Ajami, A. P. Weetman, C. J. Strasburger, and R. J. M. Ross
High-Dose Leptin Activates Human Leukocytes Via Receptor Expression on Monocytes
J. Immunol., October 15, 2001; 167(8): 4593 - 4599.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
S. Yang, H. Lin, and A. M. Diehl
Fatty liver vulnerability to endotoxin-induced damage despite NF-{kappa}B induction and inhibited caspase 3 activation
Am J Physiol Gastrointest Liver Physiol, August 1, 2001; 281(2): G382 - G392.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
H. Tilg and A. M. Diehl
Cytokines in Alcoholic and Nonalcoholic Steatohepatitis
N. Engl. J. Med., November 16, 2000; 343(20): 1467 - 1476.
[Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
G. Fantuzzi and R. Faggioni
Leptin in the regulation of immunity, inflammation, and hematopoiesis
J. Leukoc. Biol., October 1, 2000; 68(4): 437 - 446.
[Abstract] [Full Text]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
D. L. Drazen, L. J. Kriegsfeld, J. E. Schneider, and R. J. Nelson
Leptin, but not immune function, is linked to reproductive responsiveness to photoperiod
Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2000; 278(6): R1401 - R1407.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
G. Fruhbeck, J. Salvador, B. Chandrasekar, D. H. Mitchell, J. T. Colston, and G. L. Freeman
Is Leptin Involved in the Signaling Cascade After Myocardial Ischemia and Reperfusion? Response
Circulation, May 9, 2000; 101 (18): e194 - e194.
[Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
R. Faggioni, A. Moser, K. R. Feingold, and C. Grunfeld
Reduced Leptin Levels in Starvation Increase Susceptibility to Endotoxic Shock
Am. J. Pathol., May 1, 2000; 156(5): 1781 - 1787.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
B. N. Finck and R. W. Johnson
Tumor necrosis factor (TNF)-alpha induces leptin production through the p55 TNF receptor
Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2000; 278(2): R537 - R543.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
R. Thieringer, J. E. Fenyk-Melody, C. B. Le Grand, B. A. Shelton, P. A. Detmers, E. P. Somers, L. Carbin, D. E. Moller, S. D. Wright, and J. Berger
Activation of Peroxisome Proliferator-Activated Receptor {gamma} Does Not Inhibit IL-6 or TNF-{alpha} Responses of Macrophages to Lipopolysaccharide In Vitro or In Vivo
J. Immunol., January 15, 2000; 164(2): 1046 - 1054.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
R. Faggioni, J. Jones-Carson, D. A. Reed, C. A. Dinarello, K. R. Feingold, C. Grunfeld, and G. Fantuzzi
Leptin-deficient (ob/ob) mice are protected from T cell-mediated hepatotoxicity: Role of tumor necrosis factor alpha and IL-18
PNAS, February 29, 2000; 97(5): 2367 - 2372.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online