AJP - Regu Information on EB 2010
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 276: R251-R258, 1999;
0363-6119/99 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Schreihofer, A. M.
Right arrow Articles by Stricker, E. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Schreihofer, A. M.
Right arrow Articles by Stricker, E. M.
Vol. 276, Issue 1, R251-R258, January 1999

Thirst and salt appetite elicited by hypovolemia in rats with chronic lesions of the nucleus of the solitary tract

Ann M. Schreihofer, Brett K. Anderson, Jennifer C. Schiltz, Ling Xu, Alan F. Sved, and Edward M. Stricker

Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260

Cardiac vagal afferents terminating in the nucleus of the solitary tract (NTS) are believed to participate in stimulating neurohypophysial secretion of vasopressin as well as increased ingestion of water and NaCl solution in response to decreased blood volume. However, we recently reported that chronic lesions of NTS, which eliminate neural input from cardiac and arterial baroreceptors, do not impair hypovolemia-induced vasopressin secretion in rats. In the present investigation we sought to determine whether those sensory signals were necessary for hypovolemia-induced thirst and salt appetite. Rats with chronic lesions of the NTS increased consumption of water and NaCl solution normally when plasma volume was reduced isosmotically by subcutaneous injection of polyethylene glycol solution. These results were obtained whether rats were allowed to drink water or 0.15 M NaCl in one-bottle tests or water and 0.5 M NaCl in two-bottle tests. The induction of thirst and salt appetite by hypovolemia despite the apparent loss of neural input to the brain from cardiac volume-sensitive receptors indicates that other signals generated by plasma volume deficits can stimulate these behavioral responses in rats.

baroreceptors; sodium chloride; volume regulation; water


This article has been cited by other articles:


Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
E. Lazartigues, P. Sinnayah, G. Augoyard, C. Gharib, A. K. Johnson, and R. L. Davisson
Enhanced water and salt intake in transgenic mice with brain-restricted overexpression of angiotensin (AT1) receptors
Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2008; 295(5): R1539 - R1545.
[Abstract] [Full Text] [PDF]

Home page
 Exp PhysiolHome page
J. C. Geerling and A. D. Loewy
Central regulation of sodium appetite
Exp Physiol, February 1, 2008; 93(2): 177 - 209.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
J. C. Geerling and A. D. Loewy
Sodium depletion activates the aldosterone-sensitive neurons in the NTS independently of thirst
Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2007; 292(3): R1338 - R1348.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
A. M. Schreihofer, S. Ito, and A. F. Sved
Brain stem control of arterial pressure in chronic arterial baroreceptor-denervated rats
Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2005; 289(6): R1746 - R1755.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
S. D. Stocker, J. C. Schiltz, and A. F. Sved
Acute increases in arterial blood pressure do not reduce plasma vasopressin levels stimulated by angiotensin II or hyperosmolality in rats
Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2004; 287(1): R127 - R137.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
J. ANTUNES-RODRIGUES, M. DE CASTRO, L. L. K. ELIAS, M. M. VALENCA, and S. M. McCANN
Neuroendocrine Control of Body Fluid Metabolism
Physiol Rev, January 1, 2004; 84(1): 169 - 208.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
W. Huang, M. Sjoquist, O. Skott, E. M. Stricker, and A. F. Sved
Oxytocin antagonist disrupts hypotension-evoked renin secretion and other responses in conscious rats
Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2001; 280(3): R760 - R765.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
A. M. Schreihofer, E. M. Stricker, and A. F. Sved
Nucleus of the solitary tract lesions enhance drinking, but not vasopressin release, induced by angiotensin
Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2000; 279(1): R239 - R247.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
W. Huang, M. Sjoquist, O. Skott, E. M. Stricker, and A. F. Sved
Oxytocin-induced renin secretion in conscious rats
Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2000; 278(1): R226 - R230.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
T. N. Thrasher, C. R. Keenan, and D. J. Ramsay
Cardiovascular afferent signals and drinking in response to hypotension in dogs
Am J Physiol Regulatory Integrative Comp Physiol, September 1, 1999; 277(3): R795 - R801.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
S. Ito, F. J. Gordon, and A. F. Sved
Dietary salt intake alters cardiovascular responses evoked from the rostral ventrolateral medulla
Am J Physiol Regulatory Integrative Comp Physiol, June 1, 1999; 276(6): R1600 - R1607.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online