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-estradiol on
parasympathetic tone in male rats
Department of Anatomy and Physiology, Atlantic Veterinary College, University of Prince Edward Island, Charlottetown, Prince Edward Island, Canada C1A 4P3
The following experiments were conducted to
determine if peripherally administered estrogen has an effect on
central autonomic tone and whether this change in tone results in an
alteration in cardiovascular reflex control. Male Sprague-Dawley rats
were anesthetized with thiobutabarbitol sodium (50 mg/kg) and
instrumented to record blood pressure, heart rate, and vagal
parasympathetic or renal sympathetic efferent nerve activity.
Additional rats were instrumented to test the sensitivity of the
cardiac baroreflex using intravenous injections of phenylephrine
hydrochloride (0.025, 0.05, 0.1 mg/kg) or sodium nitroprusside (0.0025, 0.005, 0.01 mg/kg) and plotting the cardiovascular responses.
Intravenous injection of estrogen
(10
4,
102, and
101 mg/kg) produced a
significant increase in vagal efferent activity and in baroreflex
sensitivity. The bilateral microinjection of an estrogen receptor
antagonist, ICI-182,780 (1 pM, 50 nl/side) into the nucleus ambiguus
blocked both the estrogen-induced increase in vagal efferent activity
and baroreflex sensitivity. These results demonstrate that in male rats
estrogen acts centrally to enhance baroreflex sensitivity by increasing
parasympathetic efferent tone.
renal nerve; vagus nerve; ICI-182,780; nucleus ambiguus; baroreflex sensitivity
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