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1 Department of Cardiovascular Dynamics, The National Cardiovascular Center Research Institute, Osaka 565, Japan; and 2 Department of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee 37235
We earlier
reported that stimulation of either one of the sympathetic and vagal
nerves augments the dynamic heart rate (HR) response to concurrent
stimulation of its counterpart. We explained this phenomenon by
assuming a sigmoidal static relationship between nerve activity and HR.
To confirm this assumption, we stimulated the sympathetic
and/or vagal nerve in anesthetized rabbits using large-amplitude Gaussian white noise and determined the static and
dynamic characteristics of HR regulation by a neural network analysis.
The static characteristics approximated a sigmoidal relationship
between the linearly predicted and the measured HRs (response range:
212.4 ± 46.3 beats/min, minimum HR: 96.0 ± 28.4 beats/min,
midpoint of operation: 196.7 ± 31.3 beats/min, maximum slope: 1.65 ± 0.51). The maximum step responses determined from the dynamic
characteristics were 7.9 ± 2.9 and 
14.0 ± 4.9 beats · min
1 · Hz1
for the sympathetic and the vagal system, respectively. Because of
these characteristics, changes in sympathetic or vagal tone alone can
alter the dynamic HR response to stimulation of the other nerve.
systems analysis; Gaussian white noise; neural network; nerve stimulation; rabbits
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