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Am J Physiol Regul Integr Comp Physiol 276: R1141-R1148, 1999;
0363-6119/99 $5.00
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Vol. 276, Issue 4, R1141-R1148, April 1999

Cholinergic systems in the nucleus of the solitary tract of rats

Miwako Shihara1, Nobuaki Hori2, Yoshitaka Hirooka1, Kenichi Eshima1, Norio Akaike3, and Akira Takeshita1

1 Research Institute of Angiocardiology and Cardiovascular Clinic; 3 Department of Physiology, Kyushu University School of Medicine; and 2 Department of Pharmacology, Kyushu University School of Dentistry, Fukuoka 812-8582, Japan

The pharmacological and physiological properties of excitatory amino acid and ACh systems in the nucleus of the solitary tract (NTS) were studied in slices of rat brain stem by extracellular and intracellular recordings from neurons activated by solitary tract (ST) stimulation. These neurons were characterized as having several long dendrites with multiple varicosities. Synaptic activation of the medial NTS (mNTS) neurons by ST stimulation was mediated by non-N-methyl-D-aspartate (NMDA) glutamate (Glu) receptors, because the excitation was blocked by 6-cyano-7-nitro-quinoxaline-2,3-dione but not by NMDA, nicotinic, or muscarinic antagonists. Identified mNTS neurons were excited by iontophoresis of both Glu and ACh. The most sensitive region of the cell was on the dendrites ~100 µm from the cell body for both putative neurotransmitters. Nicotinic and/or muscarinic excitatory ACh responses were detected on the mNTS neurons. Our observations suggest that both types of ACh receptors may contribute to the attenuation of the baroreceptor reflex, but the functional correlation of this receptor profile remains to be determined.

glutamate; brain stem


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