AJP - Regu AJP: Lung Cellular and Molecular Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 276: R1311-R1319, 1999;
0363-6119/99 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Malpas, S. C.
Right arrow Articles by Austin, P. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Malpas, S. C.
Right arrow Articles by Austin, P. C.
Vol. 276, Issue 5, R1311-R1319, May 1999

Resonance in the renal vasculature evoked by activation of the sympathetic nerves

Simon C. Malpas1, Todd A. Hore1, Michael Navakatikyan1, Elena V. Lukoshkova2, Sing Kiong Nguang3, and Paul C. Austin3

Departments of 1 Physiology and 3 Electrical Electronic Engineering, University of Auckland, New Zealand; and 2 National Cardiology Research Center, Moscow 121552, Russia

We examined the ability of different frequencies in sympathetic nerve activity (SNA) to induce oscillations in renal blood flow (RBF). In anesthetized rabbits the renal nerves were stimulated using modulated sine patterns (base frequency 5 Hz, 5-ms duration pulses) that varied in amplitude between 0 and 10 V at a frequency between 0.04 and 1.0 Hz. The strengths of the induced oscillations in RBF were calculated using spectral analysis. Although faster rhythms in simulated SNA >0.6 Hz contributed to the level of vascular tone, 95% of the power in the frequency response curve was below this frequency, indicating a low-pass filtering/integrating characteristic of the vasculature. Frequencies <0.6 Hz were associated with increasing ability to induce oscillations in RBF. The ability of an SNA rhythm at 0.6 Hz to induce a rhythm in RBF was 21 times less than that at 0.25 Hz. At 0.16 Hz there was a distinct peak in the frequency response curve, indicating the vasculature was more sensitive in this frequency band to sympathetic stimulation. Blockade of endogenous nitric oxide by NG-nitro-L-arginine methyl ester (L-NAME; 20 mg/kg) did not alter resting RBF levels nor was the low-pass filtering/integrating characteristic of the vasculature to nerve stimulation changed (i.e., the curve was not shifted left or right); however, there was a selective increase in the sensitivity to stimulation at 0.16 Hz, i.e., larger oscillations in RBF were evoked. These results indicate an ability of SNA to induce resonant oscillations in the renal vasculature and that there may be active and passive modulators of these responses. Naturally occurring oscillations in SNA <0.6 Hz are likely to contribute to the dynamic control of RBF, ensuring it responds rapidly and with high gain to the stimuli of daily life, while filtering out the faster oscillations ensures stable glomerular filtration.

rabbit; sympathetic nervous system; spectral analysis; nitric oxide


This article has been cited by other articles:


Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
S. C. Malpas
What sets the long-term level of sympathetic nerve activity: is there a role for arterial baroreceptors?
Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2004; 286(1): R1 - R12.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
T. Soderstrom, A. Stefanovska, M. Veber, and H. Svensson
Involvement of sympathetic nerve activity in skin blood flow oscillations in humans
Am J Physiol Heart Circ Physiol, May 1, 2003; 284(5): H1638 - H1646.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
G. F. DiBona and L. L. Sawin
Effect of renal nerve stimulation on responsiveness of the rat renal vasculature
Am J Physiol Renal Physiol, November 1, 2002; 283(5): F1056 - F1065.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
O. Grisk and H. M. Stauss
Frequency modulation of mesenteric and renal vascular resistance
Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2002; 282(5): R1468 - R1476.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
K. M. Denton, A. Shweta, and W. P. Anderson
Preglomerular and Postglomerular Resistance Responses to Different Levels of Sympathetic Activation by Hypoxia
J. Am. Soc. Nephrol., January 1, 2002; 13(1): 27 - 34.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
S. C. Malpas
Neural influences on cardiovascular variability: possibilities and pitfalls
Am J Physiol Heart Circ Physiol, January 1, 2002; 282(1): H6 - H20.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
S.-J. Guild, P. C. Austin, M. Navakatikyan, J. V. Ringwood, and S. C. Malpas
Dynamic relationship between sympathetic nerve activity and renal blood flow: a frequency domain approach
Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2001; 281(1): R206 - R212.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
J. V. Ringwood and S. C. Malpas
Slow oscillations in blood pressure via a nonlinear feedback model
Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2001; 280(4): R1105 - R1115.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
D. Bertram, C. Barres, Y. Cheng, and C. Julien
Norepinephrine reuptake, baroreflex dynamics, and arterial pressure variability in rats
Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2000; 279(4): R1257 - R1267.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
B. L. Leonard, R. G. Evans, M. A. Navakatikyan, and S. C. Malpas
Differential neural control of intrarenal blood flow
Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2000; 279(3): R907 - R916.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
S. C. Malpas and D. E. Burgess
Renal SNA as the primary mediator of slow oscillations in blood pressure during hemorrhage
Am J Physiol Heart Circ Physiol, September 1, 2000; 279(3): H1299 - H1306.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
B. J. A. Janssen, P. J. A. Leenders, and J. F. M. Smits
Short-term and long-term blood pressure and heart rate variability in the mouse
Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2000; 278(1): R215 - R225.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
B. J. A. Janssen, E. V. Lukoshkova, and G. A. Head
Sympathetic modulation of renal blood flow by rilmenidine and captopril: central vs. peripheral effects
Am J Physiol Renal Physiol, January 1, 2002; 282(1): F113 - F123.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online