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Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, Washington State University, Pullman, Washington 99164
Various
growth factors are involved in sleep regulation. Brain-derived
neurotrophic factor (BDNF) belongs to the neurotrophin family; it and
its receptors are found in normal brain. Furthermore, cerebral cortical
levels of BDNF mRNA have a diurnal variation and increase after sleep
deprivation. Therefore, we investigated whether BDNF would promote
sleep. Twenty-four male Sprague-Dawley rats (320-380 g) and 25 male New Zealand White rabbits (4.5-5.5 kg) were surgically
implanted with electroencephalographic (EEG) electrodes, a brain
thermistor, and a lateral intracerebroventricular cannula. The animals
were injected intracerebroventricularly with pyrogen-free saline and,
on a separate day, one of the following doses of BDNF: 25 or 250 ng in
rabbits; 10, 50, or 250 ng in rats. The EEG, brain temperature, and
motor activity were recorded for 23 h after the intracerebroventricular
injections. BDNF increased time spent in non-rapid eye movement sleep
(NREMS) in rats and rabbits and REMS in rabbits. Current results
provide further evidence that various growth factors are involved in
sleep regulation.
neurotrophin-2; rapid eye movement sleep; growth factor; brain temperature; slow-wave sleep
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