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Am J Physiol Regul Integr Comp Physiol 276: R1461-R1468, 1999;
0363-6119/99 $5.00
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Vol. 276, Issue 5, R1461-R1468, May 1999

Prevention of stress-induced weight loss by third ventricle CRF receptor antagonist

Gennady N. Smagin, Leigh Anne Howell, Stephen Redmann Jr., Donna H. Ryan, and Ruth B. S. Harris

Departments of Neuroscience and Biostatistics, Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808

We previously reported that rats exposed to repeated restraint (3 h/day for 3 days) experience temporary hypophagia and a sustained reduction in body weight compared with nonrestrained controls. Studies described here determined the involvement of central corticotropin-releasing factor (CRF) receptors in the initiation of this chronic response to acute stress. In experiment 1, Sprague-Dawley rats were fitted with cannulas in the lateral ventricle and infused with 50 µg of alpha hCRF-(9---41) or saline immediately before restraint on each of the 3 days of restraint. The receptor antagonist inhibited hypophagia and weight loss on day 1 of restraint but not on days 2 and 3. In experiment 2, 10 µg of alpha hCRF-(9---41) or saline were infused into the third ventricle immediately before each restraint. The receptor antagonist totally blocked stress-induced hypophagia and weight loss. These results demonstrate that CRF receptors located in or near the hypothalamus mediate the acute responses to stress that lead to a permanent change in the hormonal or metabolic processes that determine body weight and body composition.

alpha hCRF-(9---41); restraint stress; food intake


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