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Am J Physiol Regul Integr Comp Physiol 277: R190-R197, 1999;
0363-6119/99 $5.00
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Vol. 277, Issue 1, R190-R197, July 1999

Pulmonary artery endothelium-dependent vasodilation is impaired in a chicken model of pulmonary hypertension

Luis A. Martinez-Lemus1, R. Kelly Hester2, Elizabeth J. Becker2, Joan S. Jeffrey3, and Ted W. Odom1

Departments of 1 Poultry Science, 2 Medical Pharmacology and Toxicology, and 3 Veterinary Pathobiology/Veterinary Extension, Texas Agricultural Experiment Station and Colleges of Medicine and Veterinary Medicine, Texas A&M University, College Station, Texas 77843

Among chicken strains, broilers are prone to pulmonary hypertension, whereas Leghorns are not. Relaxations to endothelium-dependent (ACh, A23187) and endothelium-independent [sodium nitroprusside (SNP), papaverine (PPV)] vasodilators were compared in preconstricted pulmonary artery (PA) rings from these chicken strains. ACh (10-7, 10-6, and 10-5 M)- and A23187 (10-6 and 10-5.5 M)-induced relaxations were smaller (P < 0.05) in broilers than Leghorns. NG-nitro-L-arginine methyl ester (10-3.5 M) caused similar reductions in ACh-induced relaxations in both strains. L-Arginine (10-4 M) enhanced ACh-induced relaxations more in broilers than Leghorns. Relaxations to 10-10-10-6 M SNP did not differ between strains, but were greater (P < 0.05) in broilers than Leghorns at higher concentrations (10-5 and 10-4 M). PPV (10-4 M)- and SNP (10-4 M)-induced maximal relaxations were greater in broilers than in Leghorns (176.2 ± 14.7 vs. 120.9 ± 14.7% and 201.3 ± 7.8 vs. 171.2 ± 10.7%, respectively, P < 0.05). Broiler PA rings appear to have increased intrinsic tone and reduced endothelium-derived nitric oxide activity, both of which may contribute to the susceptibility of broiler chickens to pulmonary hypertension.

broiler chicken; Leghorn chicken; nitric oxide; intrinsic tone


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