| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, and Program in Neuroscience, Washington State University, Pullman, Washington 99164
When rats are maintained on high-fat diets, digestive processes adapt to provide for more efficient digestion and absorption of this nutrient. Furthermore, rats fed high-fat diets tend to consume more calories and gain more weight than rats on a low-fat diet. We hypothesized that, in addition to adaptation of digestive processes, high-fat maintenance diets might result in reduction of sensitivity to the satiating effects of fat digestion products, which inhibit food intake by activating sensory fibers in the small intestine. To test this hypothesis we measured food intake after intestinal infusion of oleic acid or the oligosaccharide maltotriose in rats maintained on a low-fat diet or one of three high-fat diets. We found that rats fed high-fat diets exhibited diminished sensitivity to satiation by intestinal infusion of oleic acid. Sensitivity to the satiation effect of intestinal maltotriose infusion did not differ between groups maintained on the various diets. Reduced sensitivity to oleate infusion was specifically dependent on fat content of the diet and was not influenced by the dietary fiber or carbohydrate content. These results indicate that diets high in fat reduce the ability of fat to inhibit further food intake. Such changes in sensitivity to intestinal fats might contribute to the increased food intake and obesity that occur with high-fat diet regimens.
fat adaptation; maltotriose; cholecystokinin
This article has been cited by other articles:
|
|
 |
|
  T. J. Little, K. L. Feltrin, M. Horowitz, J. H. Meyer, J. Wishart, I. M. Chapman, and C. Feinle-Bisset A high-fat diet raises fasting plasma CCK but does not affect upper gut motility, PYY, and ghrelin, or energy intake during CCK-8 infusion in lean men Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2008; 294(1): R45 - R51. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. A. Boyd, D. G. O'Donovan, S. Doran, J. Wishart, I. M. Chapman, M. Horowitz, and C. Feinle High-fat diet effects on gut motility, hormone, and appetite responses to duodenal lipid in healthy men Am J Physiol Gastrointest Liver Physiol, February 1, 2003; 284(2): G188 - G196. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. E. Castiglione, N. W. Read, and S. J. French Adaptation to high-fat diet accelerates emptying of fat but not carbohydrate test meals in humans Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2002; 282(2): R366 - R371. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. J. Kalogeris and R. G. Painter Adaptation of intestinal production of apolipoprotein A-IV during chronic feeding of lipid Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2001; 280(4): R1155 - R1161. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Covasa, J. K. Marcuson, and R. C. Ritter Diminished satiation in rats exposed to elevated levels of endogenous or exogenous cholecystokinin Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2001; 280(2): R331 - R337. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Lin, R. Martin, A. O. Schaffhauser, and D. A. York Acute changes in the response to peripheral leptin with alteration in the diet composition Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2001; 280(2): R504 - R509. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Covasa and R. C. Ritter Adaptation to high-fat diet reduces inhibition of gastric emptying by CCK and intestinal oleate Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2000; 278(1): R166 - R170. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
