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Am J Physiol Regul Integr Comp Physiol 277: R295-R300, 1999;
0363-6119/99 $5.00
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Vol. 277, Issue 1, R295-R300, July 1999

Muscle IMP accumulation during fatiguing submaximal exercise in endurance trained and untrained men

Jacinta Baldwin1, Rodney J. Snow2, Michael F. Carey3, and Mark A. Febbraio1

1 Exercise Physiology and Metabolism Laboratory, Department of Physiology, The University of Melbourne, Parkville, 3052 Victoria; 2 School of Human Movement, Deakin University, Burwood, 3125 Victoria; and 3 Exercise Metabolism Unit, Department of Biomedical Sciences, Victoria University of Technology, Footscray, 3011 Victoria, Australia

To examine the effect of training status on muscle metabolism during exercise, seven endurance-trained [peak oxygen uptake (VO2 peak) = 65.8 ± 2.4 ml · kg-1 · min-1] and six untrained (VO2 peak = 46.2 ± 1.9 ml · kg-1 · min-1) men cycled to fatigue at a work rate calculated to require 70% VO2 peak. Time to exhaustion was 36% longer (P < 0.01) in trained (TR) compared with untrained (UT) men (148 ± 11 vs. 95 ± 8 min). Although intramuscular glycogen content was reduced (P < 0.05) in both TR and UT at fatigue, IMP, a marker of a mismatch between ATP supply and demand, was only elevated (P < 0.01) in UT muscle at fatigue and was approximately fourfold higher at this point in UT compared with TR. These data demonstrate that fatiguing submaximal exercise was associated with a similar low level of intramuscular glycogen in both TR and UT men, but a mismatch between ATP supply and demand only occurred in UT individuals.

muscle metabolism; glycogen; adenosine 5'-triphosphate supply and demand; inosine monophosphate


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