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Am J Physiol Regul Integr Comp Physiol 277: R39-R46, 1999;
0363-6119/99 $5.00
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Vol. 277, Issue 1, R39-R46, July 1999

Volume expansion does not activate neuronal projections from the NTS or depressor VLM to the RVLM

Anthony D. Shafton, Andrew Ryan, Barry McGrath, and Emilio Badoer

Department of Medicine, Monash Medical Centre, Monash University, Clayton 3168, Melbourne, Victoria, Australia

We investigated whether a monosynaptic connection from the nucleus tractus solitarius (NTS) or the depressor ventrolateral medulla (VLM) to the pressor region of the rostral VLM (RVLM) constituted part of the reflex pathway activated by cardiopulmonary baroreceptors. Volume expansion in the conscious rabbit, which elicits renal nerve inhibition predominantly via cardiac mechanoreceptors, was used as the stimulus. The protein Fos was used as a marker of neuronal activation. The retrogradely transported tracer rhodamine-tagged microspheres, previously injected into the pressor region of the RVLM, identified medullary neurons that projected to that region. Volume expansion significantly increased the number of Fos-positive cell nuclei in the NTS and in the depressor VLM. Neurons that projected to the RVLM were found throughout the depressor region of the VLM and in the NTS but were not activated by volume expansion. Thus, although the central reflex pathways activated by volume expansion include the NTS and the depressor region of the VLM, we could not find evidence for a monosynaptic connection between those regions and the RVLM.

cardiac mechanoreceptors; medulla oblongata; Fos immunohistochemistry; central nervous system pathways; nucleus tractus solitarius; rostral ventrolateral medulla


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