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Departments of Psychology and Pharmacology and the Cardiovascular Center, University of Iowa, Iowa City, Iowa 52242-1407
We examined
the role of the subfornical organ (SFO) in stimulating thirst and salt
appetite using two procedures that initiate water and sodium ingestion
within 1-2 h of extracellular fluid depletion. The first procedure
used injections of a diuretic (furosemide, 10 mg/kg sc) and a
vasodilator (minoxidil, 1-3 mg/kg ia) to produce hypotension
concurrently with hypovolemia. The resulting water and sodium intakes
were inhibited by intravenous administration of ANG II receptor
antagonist (sarthran, 8 µg · kg
1 · min1)
or angiotensin-converting enzyme inhibitor (captopril, 2.5 mg/h). The
second procedure used injections of furosemide (10 mg/kg sc) and a low
dose of captopril (5 mg/kg sc) to initiate water and sodium ingestion
upon formation of ANG II in the brain. Electrolytic lesions of the SFO
greatly reduced the water intakes, and nearly abolished the sodium
intakes, produced by these relatively acute treatments. These results
contrast with earlier findings showing little effect of SFO lesions on
sodium ingestion after longer-term extracellular fluid depletion.
water intake; sodium intake; hypovolemia; hypotension; arterial pressure; angiotensin II
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