AJP - Regu Add DOIs to your references at manuscript stage!
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 277: R337-R345, 1999;
0363-6119/99 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Melanson, K. J.
Right arrow Articles by Campfield, L. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Melanson, K. J.
Right arrow Articles by Campfield, L. A.
Vol. 277, Issue 2, R337-R345, August 1999

Blood glucose patterns and appetite in time-blinded humans: carbohydrate versus fat

Kathleen J. Melanson1, Margriet S. Westerterp-Plantenga1, Wim H. M. Saris1, Françoise J. Smith2, and L. Arthur Campfield2

1 Department of Human Biology, Maastricht University, 6200 MD Maastricht, The Netherlands; and 2 Center for Human Nutrition, Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262

We assessed the extent to which a possible synchronization between transient blood glucose declines and spontaneous meal initiation would lend support to the interpretation of a preload study with isoenergetic (1 MJ) isovolumetric high-fat or simple carbohydrate (CHO) preload drinks. Ten men (18-30 yr) fasted overnight and then were time blinded and made aware that they could request meals anytime. At first meal requests, volunteers consumed a preload; ad libitum meals were offered at subsequent requests. Postabsorptively, transient declines in blood glucose were associated with meal requests (chi 2 = 8.29). Subsequent meal requests occurred during "dynamic declines" in blood glucose after the peak induced by drink consumption (100%). These meal requests took twice as long to occur after high-fat than after CHO preloads (fat = 126 ± 21, CHO = 65 ± 15 min), consistent with differences in interpolated 65-min satiety scores (fat = 38 ± 8.2, CHO = 16 ± 4). Postprandially, transient blood glucose declines were associated with meal requests (chi 2 = 4.30). Spontaneous meal initiations were synchronized with transient and dynamic blood glucose declines. Synchronization of intermeal interval and dynamic declines related to higher satiating efficiency from high-fat preloads than from simple CHO preloads.

glucostatic theory; food intake regulation; intermeal interval; satiety; hunger


This article has been cited by other articles:


Home page
 Physiol. GenomicsHome page
K. M. Eny, T. M. S. Wolever, B. Fontaine-Bisson, and A. El-Sohemy
Genetic variant in the glucose transporter type 2 is associated with higher intakes of sugars in two distinct populations
Physiol Genomics, May 1, 2008; 33(3): 355 - 360.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
D. E. Cummings, R. S. Frayo, C. Marmonier, R. Aubert, and D. Chapelot
Plasma ghrelin levels and hunger scores in humans initiating meals voluntarily without time- and food-related cues
Am J Physiol Endocrinol Metab, August 1, 2004; 287(2): E297 - E304.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
L. A. Campfield and F. J. Smith
Blood Glucose Dynamics and Control of Meal Initiation: A Pattern Detection and Recognition Theory
Physiol Rev, January 1, 2003; 83(1): 25 - 58.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
G. A. Bray
The Underlying Basis for Obesity: Relationship to Cancer
J. Nutr., November 1, 2002; 132(11): 3451S - 3455.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
C. Marmonier, D. Chapelot, M. Fantino, and J. Louis-Sylvestre
Snacks consumed in a nonhungry state have poor satiating efficiency: influence of snack composition on substrate utilization and hunger
Am. J. Clinical Nutrition, September 1, 2002; 76(3): 518 - 528.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
J. C Brand-Miller, S. H. Holt, D. B Pawlak, and J. McMillan
Glycemic index and obesity
Am. J. Clinical Nutrition, July 1, 2002; 76(1): 281S - 285.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
H. Laboure, V. Van Wymelbeke, M. Fantino, and S. Nicolaidis
Behavioral, plasma, and calorimetric changes related to food texture modification in men
Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2002; 282(5): R1501 - R1511.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
V. Van Wymelbeke, J. Louis-Sylvestre, and M. Fantino
Substrate oxidation and control of food intake in men after a fat-substitute meal compared with meals supplemented with an isoenergetic load of carbohydrate, long-chain triacylglycerols, or medium-chain triacylglycerols
Am. J. Clinical Nutrition, November 1, 2001; 74(5): 620 - 630.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
K. J. Melanson, M. S. Westerterp-Plantenga, L. A. Campfield, and W. H. M. Saris
Appetite and blood glucose profiles in humans after glycogen-depleting exercise
J Appl Physiol, September 1, 1999; 87(3): 947 - 954.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online