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Am J Physiol Regul Integr Comp Physiol 277: R362-R367, 1999;
0363-6119/99 $5.00
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Vol. 277, Issue 2, R362-R367, August 1999

Thermoregulatory responses of the inbred heat-tolerant FOK rat to cold

Takehiro Yahata1,2, Fujiya Furuyama3, Tomoaki Nagashima1, Mitsuru Moriya1, Kazue Kikuchi-Utsumi1, Teruo Kawada4, and Akihiro Kuroshima1

1 Department of Physiology, Asahikawa Medical College, Asahikawa 078-8510; 2 Department of Nursing, Nayoro City College, Nayoro 096-8641; 3 Department of Physiology, Nagoya City University Medical School, Nagoya 467-8601; and 4 Laboratory of Nutritional Chemistry, Department of Food Science and Technology, Faculty of Agriculture, Kyoto University, Kyoto 606-8502, Japan

The responses of inbred heat-tolerant FOK rats to cold were compared with those of Wistar King A/H (WKAH) and Std:Wistar (WSTR) strains. The fall of colonic temperature during cold exposure was unexpectedly smaller in FOK than in other groups, but the onset of shivering was delayed in FOK. Norepinephrine (NE)-induced in vivo oxygen consumption and the mitochondrial uncoupling protein 1 level of brown adipose tissue (BAT) were not different among the groups, but the cold-induced increases in in vivo oxygen consumption as well as plasma glycerol and free fatty acids were higher in FOK than in other groups. In vitro NE-induced oxygen consumption of BAT was less in FOK than WSTR, but not WKAH. The magnitude of the NE-induced increase in blood flow through BAT was higher in FOK than in other groups. These results suggest that FOK paradoxically have a high capacity for nonshivering thermogenesis in spite of their high capacity for heat tolerance, probably due to an increased lipid utilization and improved circulation of BAT.

brown adipose tissue; blood flow through brown adipose tissue; cold tolerance; nonshivering thermogenesis; oxygen consumption


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