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Institute of Physiology, University Clinics Charité, Humboldt University, Berlin 10177, Germany
The impact of sodium intake and changes in
total body sodium (TBS) for the setting of pressure-dependent renin
release (PDRR) was studied in freely moving dogs. An aortic cuff
allowed servo control of renal perfusion pressure (RPP) at preset
values. Protocols were 1) high
sodium intake (HSI), 2) low sodium
intake (LSI), 3) TBS moderately
increased (+3.1 mmol Na/kg body wt) by 20% reduction of RPP for
2-4 days, 4) large increase of
TBS (+8.2) by combining protocol
3 with aldosterone infusion, and
5) TBS reduced (
3.1) by
peritoneal dialyses. Twenty-four-hour time courses of arterial plasma
renin activity (PRA) revealed that LSI increased PRA for the first 10 h
only; afterward PRA did not differ between LSI and HSI. Reduced TBS
increased PRA constantly, and the large increase of TBS constantly
reduced PRA. PDRR stimulus-response curves (assessed 20 h after last
sodium intake) revealed an exponential relationship in each protocol.
PDRR was not changed by different sodium intake. Conversely, reduced
TBS increased PDRR markedly, whereas the large increase of TBS
suppressed it. Thus an inverse relationship between TBS and PRA, i.e.,
a TBS-dependent renin release, was found. This relationship was
enhanced by decreasing RPP. This interplay between TBS-dependent renin
release and PDRR allows the organism a differentiated reaction to
changes in TBS and arterial pressure.
blood pressure; renin-angiotensin system; renal circulation; plasma renin activity; diurnal pattern
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