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Am J Physiol Regul Integr Comp Physiol 277: R667-R674, 1999;
0363-6119/99 $5.00
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Vol. 277, Issue 3, R667-R674, September 1999

Duodenal loading with glucose induces Fos expression in rat brain: selective blockade by devazepide

Lixin Wang1, Sylvain Cardin2, Vicente Martínez1, Yvette Taché1, and K. C. Kent Lloyd3

1 Center for Ulcer Research and Education/Digestive Disease Research Center, West Los Angeles Veterans Affairs Medical Center, Department of Medicine and Brain Research Institute, University of California, Los Angeles 90073; 3 School of Veterinary Medicine, University of California, Davis, California 95616; and 2 Department of Molecular Physiology and Biophysics, Vanderbilt University Medical School, Nashville, Tennessee 37232

The role of CCK in mediating neuronal activity in the brain in response to dietary carbohydrate was measured by detecting Fos immunoreactivity in response to duodenal glucose load in rats after administration of the CCK-A receptor antagonist devazepide. In adult, male Sprague-Dawley rats, infusion for 30 min of 545 mg (2.18 kcal) dextrose through a duodenal cannula induced Fos expression in the nucleus of the solitary tract (NTS), area postrema (AP), lateral division of the central nucleus of the amygdala (CeAL), and the external subnucleus of the lateral parabrachial nucleus (LPBE). Devazepide treatment (1 mg/kg) attenuated Fos expression in the NTS and AP by 81 and 78%, respectively, but not in the CeAL or LPBE. These results indicate that central neuronal activation is elicited by dietary glucose in the intestinal lumen and that activation of neurons in the NTS and AP is mediated by CCK-A receptors.

cholecystokinin; nucleus of the solitary tract; area postrema; satiety; feeding


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