AJP - Regu Watch the video to see how APS reaches out to developing nations.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 277: R786-R794, 1999;
0363-6119/99 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Cheng, C.-L.
Right arrow Articles by de Groat, W. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Cheng, C.-L.
Right arrow Articles by de Groat, W. C.
Vol. 277, Issue 3, R786-R794, September 1999

Effect of capsaicin on the micturition reflex in normal and chronic spinal cord-injured cats

Chen-Li Cheng1,2, Jiang-Chuan Liu3, Sun-Yran Chang2, Cheng-Ping Ma2, and William C. de Groat4

1 Division of Urology, Department of Surgery, Taichung Veterans General Hospital, Taichung 407; 2 Division of Urology, Department of Surgery, Tri-Service General Hospital, Taipei 100; 3 Department of Biology and Anatomy, National Defense Medical Center, Taipei 100, Taiwan, Republic of China; and 4 Department of Pharmacology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261

The effect of capsaicin (10-80 mg/kg sc) on reflex activity of the urinary bladder was examined in anesthetized normal as well as anesthetized and awake chronic spinal cord-injured (SCI) cats. In normal cats, capsaicin elicited a transient increase in the frequency of isovolumetric bladder contractions and reduced the volume threshold for inducing micturition, but did not depress the amplitude of bladder contractions or the reflex firing on bladder nerves. In anesthetized SCI cats, capsaicin depressed reflex bladder activity and firing on bladder nerves. In awake SCI cats, capsaicin initially decreased the volume threshold for inducing micturition; however, after a delay of 3-6 h the volume threshold increased and intravesical voiding pressure decreased. This effect persisted for 4-12 days. It is concluded that capsaicin-sensitive C fiber bladder afferents are not involved in initiating reflex micturition in normal cats, but play an essential role in triggering automatic micturition in chronic SCI cats. The results are consistent with the clinical data indicating that C fiber bladder afferents contribute to bladder hyperactivity and incontinence in patients with neurogenic bladder dysfunction.

urinary bladder; spinal cord injury; C fiber afferents; detrusor hyprerreflexia


This article has been cited by other articles:


Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
X. Zhang, K. L. Douglas, H. Jin, B. M. Eldaif, R. Nassar, M. O. Fraser, and P. C. Dolber
Sprouting of substance P-expressing primary afferent central terminals and spinal micturition reflex NK1 receptor dependence after spinal cord injury
Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2008; 295(6): R2084 - R2096.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
M. Miyazato, K. Sasatomi, S. Hiragata, K. Sugaya, M. B. Chancellor, W. C. de Groat, and N. Yoshimura
Suppression of detrusor-sphincter dysynergia by GABA-receptor activation in the lumbosacral spinal cord in spinal cord-injured rats
Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2008; 295(1): R336 - R342.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
J. P. Woock, P. B. Yoo, and W. M. Grill
Activation and inhibition of the micturition reflex by penile afferents in the cat
Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2008; 294(6): R1880 - R1889.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
C. Tai, B. Shen, J. Wang, M. B. Chancellor, J. R. Roppolo, and W. C. de Groat
Inhibitory and excitatory perigenital-to-bladder spinal reflexes in the cat
Am J Physiol Renal Physiol, March 1, 2008; 294(3): F591 - F602.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
H.-Y. Chang, C.-L. Cheng, J.-J. J. Chen, and W. C. de Groat
Roles of glutamatergic and serotonergic mechanisms in reflex control of the external urethral sphincter in urethane-anesthetized female rats
Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2006; 291(1): R224 - R234.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online