| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1 Department of Anesthesiology and 2 Department of Physiology, Miyazaki Medical College, Miyazaki 889-1692, Japan
Nociceptin, an endogenous agonist of the opioid receptor-like1 receptor, is expressed in the hypothalamus, where it is implicated in autonomic nervous system control. However, the central actions of nociceptin on sympathetic nerve activity have not been studied. We investigated the effect of intracerebroventricularly administered nociceptin (2-10 nmol) on blood pressure, heart rate (HR), and renal sympathetic nerve activity (RSNA) in conscious rats and sinoaortic-denervated (SAD) rats. Intracerebroventricularly administered nociceptin resulted in a dose-dependent decrease in mean arterial pressure (MAP) and HR in intact rats. RSNA decreased 31.5 ± 2.1 and 19.9 ± 5.0% at a dose of 2 and 5 nmol, respectively. In SAD rats, MAP, HR, and RSNA decreased in a dose-dependent manner, and the maximum responses were larger than those in intact rats. The decrease in HR induced by nociceptin was blocked by propranolol but not by atropine, which indicates that nociceptin is acting by inhibiting cardiac sympathetic outflow. These nociceptin-induced depressor and bradycardic responses were not antagonized by pretreatment with naloxone and nocistatin. These findings suggest that central nociceptin may have a functional role in regulating cardiovascular and sympathetic nervous systems.
sinoaortic-denervated rats; atropine; propranolol; naloxone; nocistatin
This article has been cited by other articles:
|
|
 |
|
  W. Zhou, A. Mahajan, and J. C. Longhurst Spinal nociceptin mediates electroacupuncture-related modulation of visceral sympathoexcitatory reflex responses in rats Am J Physiol Heart Circ Physiol, August 1, 2009; 297(2): H859 - H865. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. D. Wainford and D. R. Kapusta Chronic high-NaCl intake prolongs the cardiorenal responses to central N/OFQ and produces regional changes in the endogenous brain NOP receptor system Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2009; 296(2): R280 - R288. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. A. Burmeister, M. A. Ansonoff, J. E. Pintar, and D. R. Kapusta Nociceptin/Orphanin FQ (N/OFQ)-Evoked Bradycardia, Hypotension, and Diuresis Are Absent in N/OFQ Peptide (NOP) Receptor Knockout Mice J. Pharmacol. Exp. Ther., September 1, 2008; 326(3): 897 - 904. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Shirasaka, D.-L. Qiu, H. Kannan, and M. Takasaki The Effects of Centrally Administered Dexmedetomidine on Cardiovascular and Sympathetic Function in Conscious Rats Anesth. Analg., December 1, 2007; 105(6): 1722 - 1728. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
