AJP - Regu AJP: Heart and Circulatory Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 277: R1076-R1083, 1999;
0363-6119/99 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Stich, V.
Right arrow Articles by Berlan, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Stich, V.
Right arrow Articles by Berlan, M.
Vol. 277, Issue 4, R1076-R1083, October 1999

Activation of antilipolytic alpha 2-adrenergic receptors by epinephrine during exercise in human adipose tissue

Vladimir Stich1, Isabelle de Glisezinski2,3, Francois Crampes2,3, Hana Suljkovicova1, Jean Galitzky3,4, Daniel Riviere2,3, Jindra Hejnova1, Max Lafontan3, and Michel Berlan3,4

1 Department of Sport Medicine, Third Faculty of Medicine, Charles University, 100 00 Praha, Czech Republic; 4 Laboratory of Medical and Clinical Pharmacology, Faculty of Medicine, 31073 Toulouse; 2 Laboratory of the Adaptations to Exercise, Purpan Hospital, 31059 Toulouse cedex; and 3 Institut National de la Santé et de la Recherche Médicale Unité 317, Paul Sabatier University, 31403, Toulouse, France

The involvement of the antilipolytic alpha 2-adrenergic pathway and the specific role of epinephrine in the control of lipolysis during exercise in adipose tissue (AT) were investigated in healthy male subjects (age: 24.1 ± 2.2 yr; body mass index: 23.0 ± 1.6). An in vitro study carried out on isolated adipocytes showed that the weak lipolytic effect of epinephrine was potentiated after blockade of alpha 2-adrenergic receptor (AR) by an alpha 2-AR antagonist and reached that of isoproterenol, a beta -AR agonist. The effect of the nonselective alpha 2-AR antagonist phentolamine on the response of the extracellular glycerol concentration (EGC) in AT during two successive bouts of aerobic exercise (50% maximum O2 uptake, 60 min duration) was evaluated using the microdialysis method. The metabolic responses measured in perfused probes with Ringer solution were compared with those obtained in perfused probes with Ringer plus 0.1 mmol/l phentolamine. Plasma norepinephrine level was not different during the two exercise bouts, whereas that of epinephrine was 2.5-fold higher during the second exercise. EGC in AT was twofold higher in the second compared with the first exercise, and the same response pattern was found for plasma glycerol. The exercise-induced increase in EGC was higher in the probe perfused with phentolamine compared with the control probe in both bouts of exercise. However, the potentiating effect of phentolamine on EGC was significant during the second exercise bout but did not reach a significant level during the first. These results suggest that epinephrine is involved in the control of lipid mobilization through activation of antilipolytic alpha 2-AR in human subcutaneous AT during exercise.

lipolysis; microdialysis; norepinephrine; glycerol; insulin; blood flow


This article has been cited by other articles:


Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
C. Moro, J. Polak, J. Hejnova, E. Klimcakova, F. Crampes, V. Stich, M. Lafontan, and M. Berlan
Atrial natriuretic peptide stimulates lipid mobilization during repeated bouts of endurance exercise
Am J Physiol Endocrinol Metab, May 1, 2006; 290(5): E864 - E869.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
B. Mittendorfer, D. A. Fields, and S. Klein
Excess body fat in men decreases plasma fatty acid availability and oxidation during endurance exercise
Am J Physiol Endocrinol Metab, March 1, 2004; 286(3): E354 - E362.
[Abstract] [Full Text]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
I. de Glisezinski, C. Moro, F. Pillard, F. Marion-Latard, I. Harant, M. Meste, M. Berlan, F. Crampes, and D. Riviere
Aerobic training improves exercise-induced lipolysis in SCAT and lipid utilization in overweight men
Am J Physiol Endocrinol Metab, November 1, 2003; 285(5): E984 - E990.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
M. Philipp, M. Brede, and L. Hein
Physiological significance of alpha 2-adrenergic receptor subtype diversity: one receptor is not enough
Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2002; 283(2): R287 - R295.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
B. Mittendorfer, J. F. Horowitz, and S. Klein
Effect of gender on lipid kinetics during endurance exercise of moderate intensity in untrained subjects
Am J Physiol Endocrinol Metab, July 1, 2002; 283(1): E58 - E65.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
M. Flechtner-Mors, C. P. Jenkinson, A. Alt, G. Adler, and H. H. Ditschuneit
In Vivo alpha 1-Adrenergic Lipolytic Activity in Subcutaneous Adipose Tissue of Obese Subjects
J. Pharmacol. Exp. Ther., April 1, 2002; 301(1): 229 - 233.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
I. De Glisezinski, F. Marion-Latard, F. Crampes, M. Berlan, J. Hejnova, J. M. Cottet-Emard, V. Stich, and D. Riviere
Lack of {alpha}2-adrenergic antilipolytic effect during exercise in subcutaneous adipose tissue of trained men
J Appl Physiol, October 1, 2001; 91(4): 1760 - 1765.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
F. Marion-Latard, I. De Glisezinski, F. Crampes, M. Berlan, J. Galitzky, H. Suljkovicova, D. Riviere, and V. Stich
A single bout of exercise induces {beta}-adrenergic desensitization in human adipose tissue
Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2001; 280(1): R166 - R173.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
V. Stich, I. De Glisezinski, F. Crampes, J. Hejnova, J.-M. Cottet-Emard, J. Galitzky, M. Lafontan, D. Riviere, and M. Berlan
Activation of alpha 2-adrenergic receptors impairs exercise-induced lipolysis in SCAT of obese subjects
Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2000; 279(2): R499 - R504.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online