| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260
The present study sought to determine
whether central glucagon-like peptide-1 (GLP-1)-receptor signalling
contributes to the anorexigenic effects of systemically administered
lithium chloride (LiCl). Male Sprague-Dawley rats with
chronic intracerebroventricular (ICV) cannulas were acclimated to a
feeding schedule that included daily 30-min access to palatable mash.
In the first experiment, ICV infusion of a GLP-1-receptor antagonist
[exendin-4-(3
39)] significantly attenuated (10 µg dose)
or completely blocked (20 µg dose) the inhibition of food intake
produced by subsequent ICV infusion of GLP-1-(736) amide (5 µg). In
the second experiment, rats were infused with 0, 10, or 20 µg of the
GLP-1-receptor antagonist ICV, followed by injection of 0.15 M LiCl (50 mg/kg ip) or the same volume of 0.15 M NaCl. The ability of LiCl
treatment to suppress food intake was significantly attenuated in rats
that were pretreated with the GLP-1-receptor antagonist. These results
support the view that central mechanisms underlying LiCl-induced
anorexia include a prominent role for endogenous GLP-1 neural pathways.
exendin-4-(339); nausea; food intake; conditioned taste aversion
This article has been cited by other articles:
|
|
 |
|
  L. Rinaman and V. Dzmura Experimental dissociation of neural circuits underlying conditioned avoidance and hypophagic responses to lithium chloride Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2007; 293(4): R1495 - R1503. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Tang-Christensen and M. A. Cowley GLP-1 analogs: satiety without malaise? Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2007; 293(3): R981 - R982. [Full Text] [PDF]
|
|
|
|
 |
|
 S. Wan, F. H. Coleman, and R. A. Travagli Glucagon-like peptide-1 excites pancreas-projecting preganglionic vagal motoneurons Am J Physiol Gastrointest Liver Physiol, June 1, 2007; 292(6): G1474 - G1482. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Rinaman Hindbrain contributions to anorexia Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2004; 287(5): R1035 - R1036. [Full Text] [PDF]
|
|
|
|
|
|
H. J. Grill, J. S. Carmody, L. Amanda Sadacca, D. L. Williams, and J. M. Kaplan Attenuation of lipopolysaccharide anorexia by antagonism of caudal brain stem but not forebrain GLP-1-R Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2004; 287(5): R1190 - R1193. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Vrang, C. B. Phifer, M. M. Corkern, and H.-R. Berthoud Gastric distension induces c-Fos in medullary GLP-1/2-containing neurons Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2003; 285(2): R470 - R478. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Rinaman and E. E. Rothe GLP-1 receptor signaling contributes to anorexigenic effect of centrally administered oxytocin in rats Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2002; 283(1): R99 - R106. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Billig, B. J. Yates, and L. Rinaman Plasma hormone levels and central c-Fos expression in ferrets after systemic administration of cholecystokinin Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2001; 281(4): R1243 - R1255. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
