AJP - Regu AJP citation statistics
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 277: R1646-R1653, 1999;
0363-6119/99 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Harrison, A. P.
Right arrow Articles by Flatman, J. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Harrison, A. P.
Right arrow Articles by Flatman, J. A.
Vol. 277, Issue 6, R1646-R1653, December 1999

Measurement of force and both surface and deep M wave properties in isolated rat soleus muscles

A. P. Harrison and J. A. Flatman

Department of Physiology, University of Aarhus, DK-8000 Aarhus C, Denmark

In isolated soleus muscles of 4-wk-old rats, M wave parameters were recorded with surface and deep recording electrodes and examined in relation to both twitch and tetanic force. Addition of ouabain (10-5 M for 16 min) to isolated muscles caused an ~40% decrease in twitch amplitude and area (P < 0.01) that was associated with a 98% decrease in surface M wave amplitude, a 78% decrease in deep M wave amplitude (both P < 0.001), a 98% decrease in surface M wave area (P < 0.01), 48% of which occurred within 60 s of addition of ouabain (P < 0.05), and a 55% decrease in deep M wave area (P < 0.05). The decrease in twitch parameters on addition of ouabain was most closely correlated with deep M wave area (r = 0.92). Direct tetanic stimulation at a frequency of 30 Hz resulted in an initial potentiation of M waves, which was not seen at a frequency of 90 Hz. Instead, 90 Hz stimulation resulted in a prompt decrease in tetanic force that was correlated with a decrease in both deep M wave amplitude (r = 0.94; P < 0.01) and deep M wave area (r = 0.96; P < 0.01). It is concluded that simultaneous surface and deep recordings involving area and amplitude are fundamental to analysis of the effects of pharmacological agents on muscle performance and the use of M waves as predictors of muscle excitability.

skeletal muscle; compound action potential; electromyogram; ouabain; Na+-K+ pump


This article has been cited by other articles:


Home page
 Exp PhysiolHome page
V. Shushakov, C. Stubbe, A. Peuckert, V. Endeward, and N. Maassen
The relationships between plasma potassium, muscle excitability and fatigue during voluntary exercise in humans
Exp Physiol, July 1, 2007; 92(4): 705 - 715.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
I. C. H. Smith and D. J. Newham
Fatigue and functional performance of human biceps muscle following concentric or eccentric contractions
J Appl Physiol, January 1, 2007; 102(1): 207 - 213.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
C Westad and R. H Westgaard
The influence of contraction amplitude and firing history on spike-triggered averaged trapezius motor unit potentials
J. Physiol., February 1, 2005; 562(3): 965 - 975.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
T. CLAUSEN
Na+-K+ Pump Regulation and Skeletal Muscle Contractility
Physiol Rev, October 1, 2003; 83(4): 1269 - 1324.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online