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Am J Physiol Regul Integr Comp Physiol 278: R11-R18, 2000;
0363-6119/00 $5.00
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Vol. 278, Issue 1, R11-R18, January 2000

Hormonal regulation of renal sodium and water excretion during normotensive sodium loading in conscious dogs

Niels C. F. Sandgaard1, Jens Lundbæk Andersen1, and Peter Bie2

1 Department of Medical Physiology, University of Copenhagen, DK-2200 Copenhagen; and 2 Department of Physiology and Pharmacology, University of Southern Denmark, Odense, DK-5000 Odense, Denmark

.---Saline was infused intravenously for 90 min to normal, sodium-replete conscious dogs at three different rates (6, 20, and 30 µmol · kg-1 · min-1) as hypertonic solutions (HyperLoad-6, HyperLoad-20, and HyperLoad-30, respectively) or as isotonic solutions (IsoLoad-6, IsoLoad-20, and IsoLoad-30, respectively). Mean arterial blood pressure did not change with any infusion of 6 or 20 µmol · kg-1 · min-1. During HyperLoad-6, plasma vasopressin increased by 30%, although the increase in plasma osmolality (1.0 mosmol/kg) was insignificant. During HyperLoad-20, plasma ANG II decreased from 14 ± 2 to 7 ± 2 pg/ml and sodium excretion increased markedly (2.3 ± 0.8 to 19 ± 8 µmol/min), whereas glomerular filtration rate (GFR) remained constant. IsoLoad-20 decreased plasma ANG II similarly (13 ± 3 to 7 ± 1 pg/ml) concomitant with an increase in GFR and a smaller increase in sodium excretion (1.9 ± 1.0 to 11 ± 6 µmol/min). HyperLoad-30 and IsoLoad-30 increased mean arterial blood pressure by 6-7 mmHg and decreased plasma ANG II to ~6 pg/ml, whereas sodium excretion increased to ~60 µmol/min. The data demonstrate that, during slow sodium loading, the rate of excretion of sodium may increase 10-fold without changes in mean arterial blood pressure and GFR and suggest that the increase may be mediated by a decrease in plasma ANG II. Furthermore, the vasopressin system may respond to changes in plasma osmolality undetectable by conventional osmometry.

angiotensin II; volume expansion; vasopressin; blood pressure; natriuresis.


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