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1 Department of Animal Science, Cornell University, Ithaca, New York 14853; and 2 Natural Lipids, N-6160 Hovdebygda, Norway
Conjugated linoleic
acids (CLA) are octadecadienoic fatty acids that have profound effects
on lipid metabolism. Our previous work showed that CLA (mixture of
isomers) markedly reduced milk fat synthesis. In this study, our
objective was to evaluate the effects of specific CLA isomers.
Multiparous Holstein cows were used in a 3 × 3 Latin square
design, and treatments were 4-day abomasal infusions of 1) skim
milk (control), 2) 9,11 CLA supplement, and 3) 10,12 CLA supplement. CLA supplements provided 10 g/day of the specific CLA
isomer (cis-9,trans-11 or
trans-10,cis-12). Treatments had no effect on intake,
milk yield, or milk protein yield. Only the 10,12 CLA supplement
affected milk fat, causing a 42 and 44% reduction in milk fat
percentage and yield, respectively. Milk fat composition revealed that
de novo synthesized fatty acids were extensively reduced. Increases in
ratios of C14:0 to C14:1 and C18:0
to C18:1 indicated the 10,12 CLA supplement also
altered 
9-desaturase. Treatments had minimal effects
on plasma concentrations of glucose, nonesterified fatty acids,
insulin, or insulin-like growth factor-I. Overall, results demonstrate
that trans-10,cis-12 CLA is the isomer responsible for
inhibition of milk fat synthesis.
lactation; fatty acids; ruminants
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