AJP - Regu Track the topics, authors and articles important to you
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 278: R19-R27, 2000;
0363-6119/00 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (9)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Andersen, J. L.
Right arrow Articles by Bie, P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Andersen, J. L.
Right arrow Articles by Bie, P.
Vol. 278, Issue 1, R19-R27, January 2000

Volume expansion natriuresis during servo control of systemic blood pressure in conscious dogs

Jens Lundbæk Andersen1, Lars Juel Andersen1, Niels C. F. Sandgaard1, and Peter Bie2

1 Department of Medical Physiology, University of Copenhagen, DK-2200 Copenhagen; and 2 Department of Physiology and Pharmacology, University of Southern Denmark, Odense, DK-5000 Odense, Denmark

.---The importance of arterial blood pressure (BP) and ANG II for the renal natriuretic response (NaEx) to volume expansion (3.5% body wt) was investigated during converting enzyme blockade (enalaprilate, 2 mg/kg). In separate experiments, BP was clamped either 30 mmHg above or a few millimeters mercury below baseline by servo-controlled infusion of ANG II or sodium nitroprusside, respectively, so that volume expansion did not change BP. Enalapril decreased BP by 8 mmHg. Without clamping, volume expansion returned BP to that of preenalapril control and increased NaEx 10-fold (40 ± 10 to 377 ± 69 µmol/min). During high pressure clamping (133 ± 2 mmHg), peak NaEx after volume expansion was 6% of control experiments. During low pressure clamping, NaEx was 68% of control experiments (45 ± 15 to 256 ± 64 µmol/min). The results show that 1) in absence of ANG II, volume expansion elicited pronounced natriuresis without increases in BP beyond baseline, 2) in the presence of hypertensive amounts of ANG II, the volume expansion-induced natriuresis was almost eliminated, and 3) nitroprusside prevented the increase in BP but not sodium excretion during volume expansion. ANG II appears to dominate the control of NaEx; however, when absent, volume expansion may still induce marked natriuresis even at constant BP, possibly via nitric oxide-mediated mechanisms.

sodium excretion; pressure natriuresis; angiotensin II; converting enzyme inhibition; nitric oxide


This article has been cited by other articles:


Home page
 J. Physiol.Home page
E. Seeliger, J. L. Andersen, P. Bie, and H. W. Reinhardt
Elevated renal perfusion pressure does not contribute to natriuresis induced by isotonic saline infusion in freely moving dogs
J. Physiol., September 15, 2004; 559(3): 939 - 951.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
M. Schou, A. Gabrielsen, N. E. Bruun, P. Skott, B. Pump, H. Dige-Petersen, E. Frandsen, P. Bie, J. Warberg, N. J. Christensen, et al.
Angiotensin II attenuates the natriuresis of water immersion in humans
Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2002; 283(1): R187 - R196.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
L. J. Andersen, J. L. Andersen, B. Pump, and P. Bie
Natriuresis induced by mild hypernatremia in humans
Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2002; 282(6): R1754 - R1761.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
J. L. Andersen, N. C. F. Sandgaard, and P. Bie
Volume expansion during acute angiotensin II receptor (AT1) blockade and NOS inhibition in conscious dogs
Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2002; 282(4): R1140 - R1148.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
J. L. Andersen, N. C. F. Sandgaard, and P. Bie
Volume expansion during NOS substrate donation with L-arginine: regulatory offsetting of renal response?
Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2002; 282(4): R1149 - R1155.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online