| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1 Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260; 2 Department of Physiology and Medical Biophysics, Uppsala University, Uppsala 75123, Sweden; and 3 Department of Physiology, University of Odense, Odense DK-5000, Denmark
Arterial hypotension and hypovolemia
are known to stimulate neurohypophysial secretion of oxytocin (OT) in
rats, although the physiological function of OT under these
circumstances is uncertain. We now report that OT infused intravenously
into conscious rats at 125 ng · kg
1 · h1,
a dose selected to mimic plasma OT levels during hypotension or
hypovolemia, increased plasma renin concentration and plasma renin
activity by twofold. This effect was prevented by systemic pretreatment
with an OT receptor antagonist {[1-(3-mercaptopropionic acid)-2-O-ethyl-D-Tyr-Thr4-Orn8]-OT}.
The OT antagonist did not block renin secretion induced by systemic
injection of the 
-adrenergic receptor agonist isoproterenol, indicating that the OT antagonist does not interfere nonselectively with renin release. Pretreatment of rats with the -adrenergic receptor antagonist nadolol also prevented OT-induced renin secretion. Similarly, nadolol injected during infusion of OT markedly reduced the
elevated plasma renin levels. These observations raise the possibility
that pituitary OT secretion during hypotension or hypovolemia in rats
may serve to support blood pressure by enhancing activation of the
renin-angiotensin system via a -adrenergic receptor-dependent mechanism.
hypotension; -adrenergic receptors; isoproterenol; nadolol
This article has been cited by other articles:
|
|
 |
|
  I. Matsumoto, Y. Inoue, T. Shimada, T. Matsunaga, and T. Aikawa Stimulation of brain mast cells by compound 48/80, a histamine liberator, evokes renin and vasopressin release in dogs Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2008; 294(3): R689 - R698. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Chen, L. C. Carey, J. Liu, N. K. Valego, S. B. Tatter, and J. C. Rose The effect of hypothalamo-pituitary disconnection on the renin-angiotensin system in the late-gestation fetal sheep Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2005; 288(5): R1279 - R1287. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. C. Prieto-Carrasquero, L. M. Harrison-Bernard, H. Kobori, Y. Ozawa, K. S. Hering-Smith, L. L. Hamm, and L. G. Navar Enhancement of Collecting Duct Renin in Angiotensin II-Dependent Hypertensive Rats Hypertension, August 1, 2004; 44(2): 223 - 229. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Rigatto, R. Puryear, I. Bernatova, and M. Morris Salt Appetite and the Renin-Angiotensin System: Effect of Oxytocin Deficiency Hypertension, October 1, 2003; 42(4): 793 - 797. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. E. Lohmeier Neurohumoral regulation of arterial pressure in hemorrhage and heart failure Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2002; 283(4): R810 - R814. [Full Text] [PDF]
|
|
|
|
|
|
O. Skott Renin Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2002; 282(4): R937 - R939. [Full Text] [PDF]
|
|
|
|
|
|
W. Huang, M. Sjoquist, O. Skott, E. M. Stricker, and A. F. Sved Oxytocin antagonist disrupts hypotension-evoked renin secretion and other responses in conscious rats Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2001; 280(3): R760 - R765. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
