| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1 Molecular Neuroendocrinology Unit and 2 Molecular Physiology Group, Aberdeen Centre for Energy Regulation and Obesity, Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB21 9SB, United Kingdom
Siberian hamsters decreased body weight by 30% during 18 wk in short day (SD) vs. long day (LD) controls. Subsequent imposed food deprivation (FD; 24 h) caused a further 10% decrease. In the hypothalamic arcuate nucleus (ARC), SDs reduced proopiomelanocortin (POMC) gene expression and agouti-related protein (AGRP) mRNA was elevated, changes that summate to reduced catabolic drive through the melanocortin receptors. There was no effect of photoperiod on neuropeptide Y (NPY), melanin concentrating hormone, orexin, or corticotropin-releasing factor mRNAs. Superimposed FD increased AGRP gene expression and caused a localized elevation of NPY mRNA in the ARC. Both adipose tissue leptin and ARC leptin receptor (OB-Rb) mRNAs were downregulated in SDs, whereas FD increased OB-Rb gene expression. Thus OB-Rb mRNA is differentially regulated by acute and chronic changes in plasma leptin in this species. In a separate experiment in LDs, AGRP gene expression was increased by 24 or 48 h FD, whereas POMC mRNA was downregulated in the caudal ARC. AGRP and NPY mRNAs were extensively coexpressed in the ARC, and their differential regulation by photoperiod and FD is suggestive of transcript-specific regulation at the level of individual neurons.
Phodopus; agouti-related protein; proopiomelanocortin; orexins; melanin-concentrating hormone
This article has been cited by other articles:
|
|
 |
|
  C. L. Adam, P. A. Findlay, A. Chanet, R. P. Aitken, J. S. Milne, and J. M. Wallace Expression of energy balance regulatory genes in the developing ovine fetal hypothalamus at midgestation and the influence of hyperglycemia Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2008; 294(6): R1895 - R1900. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Ellis, K. M. Moar, T. J. Logie, A. W. Ross, P. J. Morgan, and J. G. Mercer Diurnal profiles of hypothalamic energy balance gene expression with photoperiod manipulation in the Siberian hamster, Phodopus sungorus Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2008; 294(4): R1148 - R1153. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Leitner and T. J. Bartness Food deprivation-induced changes in body fat mobilization after neonatal monosodium glutamate treatment Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2008; 294(3): R775 - R783. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. A. Archer, K. M. Moar, T. J. Logie, L. Reilly, V. Stevens, P. J. Morgan, and J. G. Mercer Hypothalamic neuropeptide gene expression during recovery from food restriction superimposed on short-day photoperiod-induced weight loss in the Siberian hamster Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2007; 293(3): R1094 - R1101. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. A. Archer, J. Corneloup, D. V. Rayner, P. Barrett, K. M. Moar, and J. G. Mercer Solid and Liquid Obesogenic Diets Induce Obesity and Counter-Regulatory Changes in Hypothalamic Gene Expression in Juvenile Sprague-Dawley Rats J. Nutr., June 1, 2007; 137(6): 1483 - 1490. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Tups, M. Helwig, S. Stohr, P. Barrett, J. G. Mercer, and M. Klingenspor Photoperiodic regulation of insulin receptor mRNA and intracellular insulin signaling in the arcuate nucleus of the Siberian hamster, Phodopus sungorus Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2006; 291(3): R643 - R650. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. S. Muhlhausler, C. L. Adam, P. A. Findlay, J. A. Duffield, and I. C. McMillen Increased maternal nutrition alters development of the appetite-regulating network in the brain FASEB J, June 1, 2006; 20(8): 1257 - 1259. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. E. Day, E. Keen-Rhinehart, and T. J. Bartness Role of NPY and its receptor subtypes in foraging, food hoarding, and food intake by Siberian hamsters Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2005; 289(1): R29 - R36. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. S. Muhlhausler, C. L. Adam, E. M. Marrocco, P. A. Findlay, C. T. Roberts, J. R. McFarlane, K. G. Kauter, and I. C. McMillen Impact of glucose infusion on the structural and functional characteristics of adipose tissue and on hypothalamic gene expression for appetite regulatory neuropeptides in the sheep fetus during late gestation J. Physiol., May 15, 2005; 565(1): 185 - 195. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. A. Freeman, D. A. Lewis, A. S. Kauffman, R. M. Blum, and J. Dark Reduced leptin concentrations are permissive for display of torpor in Siberian hamsters Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2004; 287(1): R97 - R103. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. E. Day and T. J. Bartness Agouti-related protein increases food hoarding more than food intake in Siberian hamsters Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2004; 286(1): R38 - R45. [Abstract] [Full Text]
|
|
|
|
 |
|
 J. Arens, K. M. Moar, S. Eiden, K. Weide, I. Schmidt, J. G. Mercer, E. Simon, and H.-W. Korf Age-dependent hypothalamic expression of neuropeptides in wild-type and melanocortin-4 receptor-deficient mice Physiol Genomics, December 16, 2003; 16(1): 38 - 46. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Weide, N. Christ, K. M. Moar, J. Arens, A. Hinney, J. G. Mercer, S. Eiden, and I. Schmidt Hyperphagia, not hypometabolism, causes early onset obesity in melanocortin-4 receptor knockout mice Physiol Genomics, March 18, 2003; 13(1): 47 - 56. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. J. Clarke, A. Rao, Y. Chilliard, C. Delavaud, and G. A. Lincoln Photoperiod effects on gene expression for hypothalamic appetite-regulating peptides and food intake in the ram Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2003; 284(1): R101 - R115. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Swart, J. W. Jahng, J. M. Overton, and T. A. Houpt Hypothalamic NPY, AGRP, and POMC mRNA responses to leptin and refeeding in mice Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2002; 283(5): R1020 - R1026. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. J. Bartness, G. E. Demas, and C. K. Song Seasonal Changes in Adiposity: the Roles of the Photoperiod, Melatonin and Other Hormones, and Sympathetic Nervous System Experimental Biology and Medicine, June 1, 2002; 227(6): 363 - 376. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. A. Cupples Regulation of body weight Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2002; 282(5): R1264 - R1266. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
