| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1 Graduate Program in Neurobiology and Behavior, Departments of 2 Obstetrics and Gynecology and 5 Physiology and Biophysics, University of Washington, Seattle, Washington 98195; 3 Amgen Corporation, Thousand Oaks, California 91320; and 4 Department of Chemistry, University of Arizona, Tucson, Arizona 85721
Leptin serves as a humoral link coupling the status of energy reserves to the functional activity of the reproductive system. Leptin is thought to act through melanocortinergic pathways in the brain to regulate ingestive behaviors; however, whether melanocortins mediate leptin's actions on the neuroendocrine-reproductive axis is unknown. We tested this hypothesis first by determining whether the effects of leptin on feeding behavior and reproduction in the ob/ob mouse could be blocked by the melanocortin receptor (MC-R) antagonist SHU9119 and second, by examining the effects of the MC-R agonist MTII on feeding and the endocrine-reproductive system. Administered by intracerebroventricular injections, leptin inhibited food intake, raised plasma gonadotropin levels, and increased seminal vesicle weights compared with controls; SHU9119 (intracerebroventricularly) attenuated leptin's effects on food intake and body weight but did not alter leptin's stimulatory effect on the reproductive axis. MTII (intracerebroventricularly and intraperitoneally) decreased food intake and increased body temperature compared with controls but had no effect on the reproductive-endocrine axis. These results suggest that although leptin acts centrally through melanocortinergic pathways to inhibit ingestive behaviors and stimulate metabolism, leptin's activational effect on the reproductive axis is likely to be mediated by other, unknown neuroendocrine circuits.
proopiomelanocortin; obesity; thermogenesis; 
-melanocyte-stimulating hormone; MTII; SHU9119
This article has been cited by other articles:
|
|
 |
|
  J. Donato Jr, R. J. Silva, L. V. Sita, S. Lee, C. Lee, S. Lacchini, J. C. Bittencourt, C. R. Franci, N. S. Canteras, and C. F. Elias The Ventral Premammillary Nucleus Links Fasting-Induced Changes in Leptin Levels and Coordinated Luteinizing Hormone Secretion J. Neurosci., April 22, 2009; 29(16): 5240 - 5250. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. K. Roseweir, A. S. Kauffman, J. T. Smith, K. A. Guerriero, K. Morgan, J. Pielecka-Fortuna, R. Pineda, M. L. Gottsch, M. Tena-Sempere, S. M. Moenter, et al. Discovery of Potent Kisspeptin Antagonists Delineate Physiological Mechanisms of Gonadotropin Regulation J. Neurosci., March 25, 2009; 29(12): 3920 - 3929. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. N. Wade and J. E. Jones Neuroendocrinology of nutritional infertility Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2004; 287(6): R1277 - R1296. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Bluher, M. Ziotopoulou, J. W. Bullen Jr, S. J. Moschos, L. Ungsunan, E. Kokkotou, E. Maratos-Flier, and C. S. Mantzoros Responsiveness to Peripherally Administered Melanocortins in Lean and Obese Mice Diabetes, January 1, 2004; 53(1): 82 - 90. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. B. Lawrence, Y.-L. Liu, M. J. Stock, and S. M. Luckman Anorectic actions of prolactin-releasing peptide are mediated by corticotropin-releasing hormone receptors Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2004; 286(1): R101 - R107. [Abstract] [Full Text]
|
|
|
|
|
|
S. Schuhler, T. L. Horan, M. H. Hastings, J. G. Mercer, P. J. Morgan, and F. J. P. Ebling Decrease of food intake by MC4-R agonist MTII in Siberian hamsters in long and short photoperiods Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2003; 284(1): R227 - R232. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. J. A. Janssen and J. F. M. Smits Autonomic control of blood pressure in mice: basic physiology and effects of genetic modification Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2002; 282(6): R1545 - R1564. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. D. Pierroz, M. Ziotopoulou, L. Ungsunan, S. Moschos, J. S. Flier, and C. S. Mantzoros Effects of Acute and Chronic Administration of the Melanocortin Agonist MTII in Mice With Diet-Induced Obesity Diabetes, May 1, 2002; 51(5): 1337 - 1345. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. A. Cupples Regulation of body weight Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2002; 282(5): R1264 - R1266. [Full Text] [PDF]
|
|
|
|
|
|
G. F. DiBona Neuropeptide Y Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2002; 282(3): R635 - R636. [Full Text] [PDF]
|
|
|
|
|
|
C. J. Small, M. S. Kim, S. A. Stanley, J. R.D. Mitchell, K. Murphy, D. G.A. Morgan, M. A. Ghatei, and S. R. Bloom Effects of Chronic Central Nervous System Administration of Agouti-Related Protein in Pair-Fed Animals Diabetes, February 1, 2001; 50(2): 248 - 254. [Abstract] [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
